- Volume 16 Issue 14
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Association between RASSF1A Promoter Hypermethylation and Oncogenic HPV Infection Status in Invasive Cervical Cancer: a Meta-analysis
- Li, Jin-Yun (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) ;
- Huang, Tao (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) ;
- Zhang, Cheng (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) ;
- Jiang, Dan-Jie (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) ;
- Hong, Qing-Xiao (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) ;
- Ji, Hui-Hui (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) ;
- Ye, Meng (The Affiliated Hospital, Ningbo University) ;
- Duan, Shi-Wei (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)
- Published : 2015.09.02
Cervical carcinoma is the main cause of cancer-related mortality in women and is correlated with more than 15 risk cofactors, including infection of cervical cells with high-risk types of HPV (hrHPV). Indeed, both aberrant methylation of the RASSF1A promoter and hrHPV infection are often observed in cervical carcinomas. The purpose of our meta-analysis was to evaluate the role of RASSF1A promoter methylation and hrHPV infection in cervical cancer. Our meta-analysis involved 895 cervical cancer patients and 454 control patients from 15 studies. Our results suggested that RASSF1A promoter hypermethylation increased the risk of cervical cancer (OR=9.77, 95%CI=[3.06, 31.26], P=0.0001,
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