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Increasing Antimicrobial Resistance Monitored in Surveillance Analysis of Blood Stream Infections in Febrile Neutropenic Pediatric Oncology Patients

  • El-Mahallawy, Hadir A (Clinical Pathology Department, National Cancer Institute, Cairo University) ;
  • Hassan, Safaa Shawky (Clinical Pathology Department, National Cancer Institute, Cairo University) ;
  • El-Wakil, Mohamed (Clinical Oncology Department, Faculty of Medicine, Beni Suef University) ;
  • Moneer, Manar M (Biostatistics and Cancer Epidemiology Department, National Cancer Institute, Cairo University) ;
  • Shalaby, Lobna (Oncology Department, National Cancer Institute, Cairo University)
  • 발행 : 2015.09.02

초록

Background: Continuous surveillance of pattern of blood stream infection is necessary in febrile neutropenia (FN)especially with the recent escalating trend in the management of pediatric cancer patients towards intensified regimens and with the increase in infections caused by resistant organisms limiting the choice of antibiotics. Aim: To monitor change in pattern of blood stream infections (BSI) in FN pediatric cancer patients. Materials and Methods: Surveillance of FN episodes with positive BSI was prospectively monitored and compared to a previous surveillance in the same pediatric oncology unit. Results: A total of 232 BSI positive episodes were documented in 192 patients during a 6 months period. The results of recent surveillance analysis showed an increase in intensified regimens of chemotherapy, antimicrobial resistance, fungal infections, and prolonged duration of episodes when compared to previous surveillance, with p value sof <0.001, 0.005, 0.021, and <0.001, respectively. There was an apparent decrease in the crude mortality but this was not statistically significant, to 6% in 2011 from 10 % in 2006. Conclusions: The pattern of BSI at our institution is still inclining towards gram positive organisms but is showing a shift towards more antibiotic resistance and fungal infections.

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피인용 문헌

  1. Presepsin as a diagnostic marker of bacterial infections in febrile neutropenic pediatric patients with hematological malignancies vol.108, pp.2, 2018, https://doi.org/10.1007/s12185-018-2447-x