- Volume 16 Issue 5
DOI QR Code
Changing Trends of Adult Lymphoma in the Kingdom of Saudi Arabia - Comparison of Data Sources
- Rauf, Muhammad Shahzad (King Faisal Specialist Hospital & Research Centre, Oncology Centre) ;
- Akhtar, Saad (King Faisal Specialist Hospital & Research Centre, Oncology Centre) ;
- Maghfoor, Irfan (King Faisal Specialist Hospital & Research Centre, Oncology Centre)
- Published : 2015.03.18
Background: Lymphoma is one of the most common malignancies affecting the young Saudi population. This disease has diversified pathologies and clinical stages that necessitate well optimized clinical management. Regular updates of epidemiological behavior of lymphoma from various parts of the world are available but studies from the Kingdom of Saudi Arabia (KSA) in this field are not consistent. Objectives: The aim of this study was to investigate the current trends in presentation and distribution of lymphoma with special reference to incidence and mortality, gender, age, histopathological subtypes, and clinical stages at King Faisal Specialist Hospital and Research Centre (KFSH&RC). Materials and Methods: Our study included lymphoma data from Saudi Cancer Registry, and relative comparison against KFSH&RC tumor registry data, Gulf country data and International Agency for Research on Cancer data. Results: Common tumors in the West (lung, colon, and prostate) were found to be much less frequent in KSA while leukemia, lymphoma and thyroid cancers were more common. Non-Hodgkin Lymphoma (NHL) ranked 3rd most common cancer with age-adjusted incidence of 6/100,000. Estimated age adjusted mortality was 4/100,000 in KSA. There was a peak rise in incidence of lymphoma in 1997-2007. Most common NHL was diffuse large B cell lymphoma at KFSH&RC. A total of 434 cases were diagnosed in 5 years with 55% of them at advanced stage and 35% demonstrating bulky disease and high risk. KFSH&RC registered 35% of Hodgkins and 21% of total NHL identified in entire Saudi Cancer Registry, 2009. Conclusions: Results of this study are very unique, and reveal diverse trends. The findings provide valuable insights in the understanding of current epidemiological features of lymphoma in this part of the world.
Lymphoma;Kingdom of Saudi Arabia;epidemiology;Saudi cancer incidence and mortality
- Ali A, Al-Belushi BS, Waly MI, et al (2013). Dietary and lifestyle factors and risk of non-Hodgkin's lymphoma in Oman. Asian Pac J Cancer Prev, 14, 841-8. https://doi.org/10.7314/APJCP.2013.14.2.841
- Balasubramaniam G, Saoba S, Sarade M, et al (2013). Casecontrol study of risk factors for Non-Hodgkin lymphoma in Mumbai, India. Asian Pac J Cancer Prev, 14, 775-80. https://doi.org/10.7314/APJCP.2013.14.2.775
- Fatima S, Ahmed R, Ahmed A (2011). Hodgkin lymphoma in Pakistan: an analysis of subtypes and their correlation with Epstein Barr virus. Asian Pac J Cancer Prev, 12, 1385-8
- Globocan, The global cancer atlas. Available from: http://globocan.iarc.fr/ia/World/atlas.html. Accessed in June 2014.
- King Faisal Specialist Hospital and Research Centre (2011). Tumor Registry Annual Report. Riyadh: Tumor Registry; Accessed June 10, 2014.
- Saudi Cancer Registry (2009). Cancer incidence report in Saudi Arabia. Riyadh: Ministry of Health.
- SEER Cancer Statistics Factsheets:National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/statfacts/html. Accessed in June 2014.
- Skibola CF (2007). Obesity, diet and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev, 16, 392-5. https://doi.org/10.1158/1055-9965.EPI-06-1081
- Ziepert M, Hasenclever D, Kuhnt E, et al (2010). Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era. J Clinical Oncol, 28, 2373-80. https://doi.org/10.1200/JCO.2009.26.2493
- Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma vol.95, pp.9, 2016, https://doi.org/10.1007/s00277-016-2736-5