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Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

  • Natphopsuk, Sitakan (Department of Physiology, Khon Kaen University) ;
  • Settheetham-Ishida, Wannapa (Department of Physiology, Khon Kaen University) ;
  • Settheetham, Dariwan (Department of Environmental Health, Khon Kaen University) ;
  • Ishida, Takafumi (Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
  • Published : 2015.03.18

Abstract

The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer was investigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients with squamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 was conducted by using two PCR methods, a short- and a long-PCR. Distribution of the GSTM1 genotypes in between the cases and the controls was not significantly different (p>0.5 by ${\chi}^2$ test). The results suggest that the GSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeast Thai women.

Keywords

Cervical cancer;GSTM1 genotype;genetic susceptibility;Northeast Thailand

Acknowledgement

Supported by : JSPS KAKENHI

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