- Volume 16 Issue 5
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Diagnostic Yield of Primary Circulating Tumor Cells in Women Suspected of Breast Cancer: the BEST (Breast Early Screening Test) Study
- Murray, Nigel P (Hematology, Medicine, Faculty of Medicine, University Mayor, Hospital de Carabineros de Chile) ;
- Miranda, Roxana (Breast Unit, Faculty of Medicine, University Mayor, Hospital de Carabineros de Chile) ;
- Ruiz, Amparo (Pathology Service, Faculty of Medicine, University Mayor, Hospital de Carabineros de Chile) ;
- Droguett, Elsa (Diagnostic Radiology, Faculty of Medicine, University Mayor, Hospital de Carabineros de Chile)
- Published : 2015.03.18
Purpose: To determine the diagnostic yield of primary circulating tumor cells in women with suspicion of breast cancer, detected as a result of an abnormal mammography. Materials and Methods: Consecutive women presenting for breast biopsy as a result of a mammogram BiRADs of 3 or more, had an 8ml blood sample taken for primary circulating tumor cell (CTC) detection. Mononuclear cells were obtained using differential gel centrifugation and CTCs identified using standard immunocytochemistry using anti-mammoglobin. A test was determined to be positive if 1 CTC was detected. Results: A total of 144 women with a mean age of
Breast cancer detection;circulating tumor cells;mammogram;mammaglobin;BiRADS
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