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Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

  • Gazel, Eymen (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Tastemur, Sedat (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Acikgoz, Onur (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Yigman, Metin (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Olcucuoglu, Erkan (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Camtosun, Ahmet (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Ceylan, Cavit (Department of Urology, Turkey Yuksek Ihtisas Training and Research Hospital) ;
  • Ates, Can (Department of Biostatistics, School of Medicine, Ankara University)
  • Published : 2015.03.18

Abstract

Background: The aim of this study was to research the importance of the neutrophil to lymphocyte ratio (NLR) in prediction of PSA recurrence after radical prostatectomy, which has not been reported so far. Materials and Methods: The data of 175 patients who were diagnosed with localised prostate cancer and underwent retropubic radical prostatectomy was retrospectively examined. Patient pre-operative hemogram parameters of neutrophil count, lymphocyte count and NLR were assessed. The patients whose PSAs were too low to measure after radical prostatectomy in their follow-ups, and then had PSAs of 0,2 ng/mL were considered as patients with PSA recurrence. Patients with recurrence made up Group A and patients without recurrence made up Group B. Results: In terms of the power of NLR value in distinguishing recurrence, the area under OCC was statistically significant (p<0.001) .The value of 2.494 for NLR was found to be a cut-off value which can be used in order to distinguish recurrence according to Youden index. According to this, patients with a higher NLR value than 2.494 had higher rates of PSA recurrence with 89.7% sensitivity and 92.6% specificity. Conclusions: There are certain parameters used in order to predict recurrence with today's literature data.We think that because NLR is easy to use in clinics and inexpensive, and also has high sensitivity and specificity values, it has the potential to be one of the parameters used in order to predict biochemical recurrence in future.

Keywords

NLR;prostate cancer;prostatectomy;PSA;recurrence

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