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IL-35 Over-expression is Associated with Genesis of Gastric Cancer

  • Fan, Yong-Gang (Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology) ;
  • Zhai, Jing-Ming (Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology) ;
  • Wang, Wei (Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology) ;
  • Feng, Bing (Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology) ;
  • Yao, Guo-Liang (Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology) ;
  • An, Yan-Hui (Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology) ;
  • Zeng, Chao (Department of Pathology, Guangdong Medical College)
  • Published : 2015.04.14

Abstract

Overexpression of interleukin (IL)-35 has been found in a variety of malignancies, but the expression status in gastric cancer has yet to be elucidated clearly. In the present study, positive expression of EBI3 and p35 was 63.3% and 70.0% of cases, respectively. EBI3 expression was strongly related with larger tumor size and invasion depth (P<0.05). Similarly, expression of p35 was also correlated with larger tumor size (P<0.05). These results indicate that IL-35 might be involved in growth of gastric cancer. Interestingly, EBI3 and p35 expressions were positive correlated with Ki-67 expression. Moreover, EBI3 immunoreactivity was associated with Bcl-2 staining. Our data suggest IL-35 is correlated with genesis of gastric cancer by regulating growth and apoptosis.

Keywords

IL-35;gastric cancer;Ki-67;Bcl-2

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