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MDR1 C3435T and C1236T Polymorphisms: Association with High-risk Childhood Acute Lymphoblastic Leukemia

  • Pongstaporn, Wanida (Pathobiology Unit, Department of Biomedical Science, Faculty of Science, Rangsit University) ;
  • Pakakasama, Samart (Department of Pediatrics, Ramathibodi Hospital, Faculty of Medicine, Mahidol University) ;
  • Chaksangchaichote, Panee (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University) ;
  • Pongtheerat, Tanett (Biochemistry Unit, Department of Biomedical Science, Faculty of Science, Rangsit University) ;
  • Hongeng, Suradej (Department of Pediatrics, Ramathibodi Hospital, Faculty of Medicine, Mahidol University) ;
  • Permitr, Songsak (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University)
  • Published : 2015.04.14

Abstract

Background: MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. Materials and Methods: To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with the occurrence and outcome of ALL, 208 children with ALL (median age 5.0 yr) and 101 healthy Thai children were studied by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) assay. Results: C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR= 2.6, 95%CI =1.164-5.808; P=0.028 and OR= 2.231, 95%CI =1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.

Keywords

Acute lymphoblastic leukemia;MDR1 polymorphism;high-risk group;Thailand

Acknowledgement

Supported by : Research Institute of Rangsit University

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