Asian Pacific Journal of Cancer Prevention
- Volume 16 Issue 7
- /
- Pages.2771-2775
- /
- 2015
- /
- 1513-7368(pISSN)
- /
- 1513-7368(eISSN)
DOI QR Code
Association between ABO Genotype and Risk of Hepatocellular Carcinoma in Koreans
- Shim, Hyung-Jeong (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital) ;
- Lee, Ran (Department of Preventive Medicine, Chonnam National University Medical School) ;
- Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School) ;
- Kim, Hee-Nam (Center for Creative Biomedical Scientists, Chonnam National University) ;
- Cho, Duck (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Ahn, Hye-Ran (Department of Nursing, Nambu University) ;
- Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University Medical School)
- Published : 2015.04.14
Abstract
Background: Associations between ABO blood groups and risk of several malignancies have been reported, although there are limited data regarding hepatocellular carcinoma (HCC). The aim of this study was to investigate any possible association between the ABO genotype, especially blood group A, and HCC risk in Koreans. Materials and Methods: We conducted a case-control study of 1,538 patients with newly diagnosed HCC at Chonnam National University Hwasun Hospital and 1,305 randomly selected members of the general population. The ABO genotype was determined by multicolor real-time polymerase chain reaction (PCR) using displacing probes. Adjusted odds ratios (aORs) and their 95% confidence intervals (CIs) were calculated using logistic regression models with adjustment for gender, age, smoking, alcohol drinking, and hepatitis B and C status. Results: The risk of HCC in genotype AA was significantly higher than in OO (aOR=1.773, 95% CI=1.161-2.705). The risk in blood group A was also higher than in blood group O (aOR=1.448, 95% CI=1.005 1.897). No significant difference was found for the AA, BO, BB, and AB genotypes, or blood group B and AB. Conclusions: Blood group A and genotype AA showed the highest risks of HCC in a Korean population. No significant difference was found for the AO, BO, BB, and AB genotypes, or blood group B and AB.
Keywords
ABO blood group;ABO genotype;hepatocellular carcinoma;case-control study
File
Acknowledgement
Supported by : Ministry for Health, Welfare and Family affairs, Chonnam National University Hwasun Hospital Research Institute of Clinical Medicine
References
- Chang UK, Kim MS, Han CJ, et al (2014). Clinical result of stereotactic radiosurgery for spinal metastasis from hepatocellular carcinoma: comparison with conventional radiation therapy. J Neurooncol, 119, 141-8. https://doi.org/10.1007/s11060-014-1463-9
- Cihan YB, Baykan H, Kavuncuoglu E, et al (2013). Relationships between skin cancers and blood groups--link between non-melanomas and ABO/Rh factors. Asian Pac J Cancer Prev, 14, 4199-203. https://doi.org/10.7314/APJCP.2013.14.7.4199
- Engin H, Bilir C, Ustun H, et al (2012). ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region. Asian Pac J Cancer Prev, 13, 131-3. https://doi.org/10.7314/APJCP.2012.13.1.131
- Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
- Garcea G, Dennison AR, Steward WP, et al (2005). Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology, 5, 514-29. https://doi.org/10.1159/000087493
- Gates MA, Wolpin BM, Cramer DW, et al (2011). ABO blood group and incidence of epithelial ovarian cancer. Int J Cancer, 128, 482-6. https://doi.org/10.1002/ijc.25339
- Hakomori S (1999). Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta, 1473, 247-66. https://doi.org/10.1016/S0304-4165(99)00183-X
- Humans. IWGotEoCRt (2004). Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum, 83, 1-1438.
- Joh HK, Cho E, Choueiri TK (2012). ABO blood group and risk of renal cell cancer. Cancer Epidemiol, 36, 528-32. https://doi.org/10.1016/j.canep.2012.07.001
- Kim YT, Choi BY, Lee KO, et al (2012). Overview of Korean Community Health Survey. J Korean Med Sci, 55, 74-83.
- Li Q, Yu CH, Yu JH, et al (2012). ABO blood group and the risk of hepatocellular carcinoma: a case-control study in patients with chronic hepatitis B. PLoS One, 7, 29928. https://doi.org/10.1371/journal.pone.0029928
- Meigs JB, Hu FB, Rifai N, et al (2004). Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA, 291, 1978-86. https://doi.org/10.1001/jama.291.16.1978
- Melzer D, Perry JR, Hernandez D, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4, 1000072. https://doi.org/10.1371/journal.pgen.1000072
- Pare G, Chasman DI, Kellogg M, et al (2008). Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet, 4, 1000118. https://doi.org/10.1371/journal.pgen.1000118
- Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
- Poole EM, Gates MA, High BA, et al (2012). ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. Cancer Causes Control, 23, 1805-10. https://doi.org/10.1007/s10552-012-0059-y
- Poujol-Robert A, Boelle PY, Wendum D, et al (2006). Association between ABO blood group and fibrosis severity in chronic hepatitis C infection. Dig Dis Sci, 51, 1633-6. https://doi.org/10.1007/s10620-006-9121-5
- Ridker PM, Hennekens CH, Roitman-Johnson B, et al (1998). Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet, 351, 88-92. https://doi.org/10.1016/S0140-6736(97)09032-6
- Ruan L, Zhao H, Li Q (2010). Multicolor real-time PCR genotyping of ABO system using displacing probes. J Forensic Sci, 55, 19-24. https://doi.org/10.1111/j.1556-4029.2009.01228.x
- Song HR, Kim HN, Piao JM, et al (2011). Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population. Mol Carcinog, 50, 871-5. https://doi.org/10.1002/mc.20796
- Song HR, Shin MH, Kim HN, et al (2013). Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population. Gastric Cancer, 16, 254-60. https://doi.org/10.1007/s10120-012-0176-z
- Terada T, Nakanuma Y (1991). Expression of ABH blood group antigens, receptors of Ulex europaeus agglutinin I, and factor VIII-related antigen on sinusoidal endothelial cells in adenomatous hyperplasia in human cirrhotic livers. Hum Pathol, 22, 486-93. https://doi.org/10.1016/0046-8177(91)90136-D
- Urun Y, Ozdemir NY, Utkan G, et al (2012). ABO and Rh blood groups and risk of colorectal adenocarcinoma. Asian Pac J Cancer Prev, 13, 6097-100. https://doi.org/10.7314/APJCP.2012.13.12.6097
- Wang DS, Chen DL, Ren C, et al (2012). ABO blood group, hepatitis B viral infection and risk of pancreatic cancer. Int J Cancer, 131, 461-8. https://doi.org/10.1002/ijc.26376
- Woo SM, Joo J, Lee WJ, et al (2013). Risk of pancreatic cancer in relation to ABO blood group and hepatitis C virus infection in Korea: a case-control study. J Korean Med Sci, 28, 247-51.
- Xie J, Qureshi AA, Li Y, et al (2010). ABO blood group and incidence of skin cancer. PLoS One, 5, 11972. https://doi.org/10.1371/journal.pone.0011972
- Yeo Y, Gwack J, Kang S, et al (2013). Viral hepatitis and liver cancer in Korea: an epidemiological perspective. Asian Pac J Cancer Prev, 14, 6227-31. https://doi.org/10.7314/APJCP.2013.14.11.6227
- Zhang BL, He N, Huang YB, et al (2014). ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 15, 4643-50. https://doi.org/10.7314/APJCP.2014.15.11.4643
- Zhou Y, Zhou Q, Lin Q, et al (2013). Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism. Int J Cancer, 133, 1867-75. https://doi.org/10.1002/ijc.28196
Cited by
- Association between ABO blood group and HCV-related hepatocellular carcinoma risk in China vol.95, pp.49, 2016, https://doi.org/10.1097/MD.0000000000005587
- Rapid ABO genotyping by high-speed droplet allele-specific PCR using crude samples pp.08878013, 2017, https://doi.org/10.1002/jcla.22196
- ABO blood type and risk of hepatocellular carcinoma: a meta-analysis vol.12, pp.9, 2018, https://doi.org/10.1080/17474124.2018.1500174