Meta-Analysis of the Association between the rs8034191 Polymorphism in AGPHD1 and Lung Cancer Risk

  • Zhang, Le (School of Life Sciences, Northwest University) ;
  • Jin, Tian-Bo (School of Life Sciences, Northwest University) ;
  • Gao, Ya (Department of Forensic Medicine, Xi'an Jiaotong University School of Medicine) ;
  • Wang, Hui-Juan (School of Life Sciences, Northwest University) ;
  • Yang, Hua (School of Life Sciences, Northwest University) ;
  • Feng, Tian (National Engineering Research Center for Miniaturized Detection Systems) ;
  • Chen, Chen (National Engineering Research Center for Miniaturized Detection Systems) ;
  • Kang, Long-Li (Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities) ;
  • Chen, Chao (School of Life Sciences, Northwest University)
  • Published : 2015.04.14


Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.


Lung cancer;single nucleotide polymorphism;AGPHD1;genetic polymorphism;meta-analysis


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