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Meta-Analysis of the Association between the rs8034191 Polymorphism in AGPHD1 and Lung Cancer Risk

  • Zhang, Le (School of Life Sciences, Northwest University) ;
  • Jin, Tian-Bo (School of Life Sciences, Northwest University) ;
  • Gao, Ya (Department of Forensic Medicine, Xi'an Jiaotong University School of Medicine) ;
  • Wang, Hui-Juan (School of Life Sciences, Northwest University) ;
  • Yang, Hua (School of Life Sciences, Northwest University) ;
  • Feng, Tian (National Engineering Research Center for Miniaturized Detection Systems) ;
  • Chen, Chen (National Engineering Research Center for Miniaturized Detection Systems) ;
  • Kang, Long-Li (Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities) ;
  • Chen, Chao (School of Life Sciences, Northwest University)
  • Published : 2015.04.14

Abstract

Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.

Keywords

Lung cancer;single nucleotide polymorphism;AGPHD1;genetic polymorphism;meta-analysis

References

  1. Amos CI, Wu X, Broderick P, et al (2008). Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 40, 616-22. https://doi.org/10.1038/ng.109
  2. Bhat IA, Pandith AA, Bhat BA, et al (2013). Lack of association of a common polymorphism in the 3' -UTR of interleukin 8 with non small cell lung cancer in Kashmir. Asian Pac J Cancer Prev. 14, 4403-8. https://doi.org/10.7314/APJCP.2013.14.7.4403
  3. Broderick P, Wang Y, Vijayakrishnan J, et al (2009). Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res, 69, 6633-41. https://doi.org/10.1158/0008-5472.CAN-09-0680
  4. Chen J, Wu X, Pande M, et al (2011). Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. Pancreas, 40, 872-5. https://doi.org/10.1097/MPA.0b013e318219dafe
  5. Egger M, Davey SG, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  6. Heller G, Zielinski CC, Zochbauer-Muller S (2010). Lung cancer: from single-gene methylation to methylome profiling. Cancer Metastasis Rev, 29, 95-107. https://doi.org/10.1007/s10555-010-9203-x
  7. Hemminki K, Lorenzo BJ, Forsti A(2006).The balance between heritable and environmental aetiology of human disease. Nat Rev Genet, 7, 958-65. https://doi.org/10.1038/nrg2009
  8. Herbst RS, Heymach JV, Lippman SM (2008). Lung cancer. N Engl J Med, 359, 1367-80. https://doi.org/10.1056/NEJMra0802714
  9. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  10. Higgins JP, Thompson SG, Deeks JJ, et al (2003).Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  11. Hung RJ, McKay JD, Gaborieau V, et al (2008). A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature, 452 ,633-7. https://doi.org/10.1038/nature06885
  12. Jaworowska E, Trubicka J, Lener MR, et al (2011). Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. PLoS One, 6, 25057. https://doi.org/10.1371/journal.pone.0025057
  13. Mantel N, HaenszelW. (1959).Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  14. Parkin DM, Pisani P, Lopez AD, et al (1994). At least one in seven cases of cancer is caused by smoking. Global estimates for 1985. Int J Cancer, 59, 494-504. https://doi.org/10.1002/ijc.2910590411
  15. Sakoda LC, Loomis MM, Doherty JA, et al (2011).Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. Cancer Causes Control, 22, 449-61. https://doi.org/10.1007/s10552-010-9716-1
  16. Schwartz AG, Cote ML, Wenzlaff AS, et al (2009). Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. J Thorac Oncol, 4, 1195-201. https://doi.org/10.1097/JTO.0b013e3181b244ef
  17. Shibuya K, Mathers CD, Boschi-Pinto C, et al (2002).Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer, 2, 37. https://doi.org/10.1186/1471-2407-2-37
  18. Shukla RK, Tilak AR, Kumar C, et al (2013). Associations of CYP1A1, GSTM1 and GSTT1 polymorphisms with lung cancer susceptibility in a Northern Indian population. Asian Pac J Cancer Prev, 14, 3345-9. https://doi.org/10.7314/APJCP.2013.14.5.3345
  19. Thorgeirsson TE, Geller F, Sulem P, et al (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452, 638-42. https://doi.org/10.1038/nature06846
  20. Truong T, Hung RJ, Amos CI, et al (2010). Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst, 102, 959-71. https://doi.org/10.1093/jnci/djq178
  21. Wang H, Zhao Y, Ma J, et al (2013). The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population. Genet Mol Res, 12 ,67-73. https://doi.org/10.4238/2013.January.22.5
  22. Wei C, Han Y, Spitz MR, et al (2011). A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. Cancer Epidemiol Biomarkers Prev, 20, 2603-9. https://doi.org/10.1158/1055-9965.EPI-11-0749
  23. Yilmaz M, Kacan T, Sari I, et al (2014). Lack of association between the MTHFRC677T polymorphism and lung cancer in a Turkish population. Asian Pac J Cancer Prev, 15, 6333-7. https://doi.org/10.7314/APJCP.2014.15.15.6333
  24. Yu K, Zhang J, Zhang J, et al (2010). Methionine synthase A2756G polymorphism and cancer risk: a meta-analysis. Eur J Hum Genet, 18, 370-8. https://doi.org/10.1038/ejhg.2009.131
  25. Zienolddiny S, Skaug V, Landvik NE, et al (2009). The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. Carcinogenesis, 30, 1368-71. https://doi.org/10.1093/carcin/bgp131