- Volume 16 Issue 8
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Induction of Apoptosis in Human Leukemic Cell Lines by Diallyl Disulfide via Modulation of EGFR/ERK/PKM2 Signaling Pathways
- Luo, Nian (Laboratory of Stem Cells and Tissue Engineering, Histology and Embryology, Chongqing Medical University) ;
- Zhao, Lv-Cui (Laboratory of Stem Cells and Tissue Engineering, Histology and Embryology, Chongqing Medical University) ;
- Shi, Qing-Qiang (Laboratory of Stem Cells and Tissue Engineering, Histology and Embryology, Chongqing Medical University) ;
- Feng, Zi-Qiang (Laboratory of Stem Cells and Tissue Engineering, Histology and Embryology, Chongqing Medical University) ;
- Chen, Di-Long (Laboratory of Stem Cells and Tissue Engineering, Histology and Embryology, Chongqing Medical University) ;
- Li, Jing (Laboratory of Stem Cells and Tissue Engineering, Histology and Embryology, Chongqing Medical University)
- Published : 2015.04.29
Background: Diallyl disulfide (DADS) may exert potent anticancer action both in vitro and in vivo. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible links between DADS and pyruvate kinase (PKM2). Materials and Methods:
Diallyl disulfide;leukemia cells;pyruvate kinase M2;apoptosis;EGFR/ERK/PKM2 signaling pathways
Supported by : National Natural Science Foundation of China
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