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Distribution of Testicular Tumors in Lebanon: A Single Institution Overview

  • Assi, Tarek (Hematology-Oncology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Rassy, Marc (Pathology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Nassereddine, Hussein (Pathology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Sader-Ghorra, Claude (Pathology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Abadjian, Gerard (Pathology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Ghosn, Marwan (Hematology-Oncology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Kattan, Joseph (Hematology-Oncology Department, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University)
  • Published : 2015.04.29

Abstract

Background: Testicular tumors constitute a rare type of cancer affecting adolescents and young adults with recent reports confirming an increase in incidence worldwide. The purpose of this study was to estimate the epidemiological characteristics and histological subtypes of testicular tumors in the Lebanese population according to the WHO classification of testicular and paratesticular tumors. Materials and Methods: In this single institutional retrospective study, all patients diagnosed with a testicular tumor in Hotel-Dieu de France Hospital University in Beirut between 1992 and 2014 were enrolled. The age, subtype based on the 2004 WHO classification and body side of tumor were analyzed. Results: A total of two hundred and forty-four (244) patients diagnosed with a testicular tumor in our institution were included in the study. Two hundred and one patients (82.4% of all testicular tumors) had germ cell tumors (TGCT). Among TGCT, 50% were seminomatous tumors, 48% non-seminomatous tumors (NST) and 2% were spermatocytic seminomas. The NST were further divided into mixed germ cell tumors (63.9%), embryonic carcinomas (18.6%), teratomas (15.4%) and yolk sac tumors (2.1%). The mean age for testicular tumors was 32 years. The mean age for germ cell tumors was 31 years and further subtypes such as seminomatous tumors had a mean age of 34 years, 28 years in non-seminomatous tumors and 56 years in spermatocytic seminoma. Patients with right testicular tumor were the predominant group with 55% of patients. Three patients (1.2%) presented with bilateral tumors. Conclusions: The distribution of different subgroups and the mean age for testicular tumors proved comparable to most countries of the world except for some Asian countries. Germ cell tumors are the most common subtype of testicular tumors with seminomatous tumors being slightly more prevalent than non-seminomatous tumors in Lebanese patients.

Keywords

Testicular tumors;WHO classification 2004;germ cell tumor;epidemiology;Lebanon

References

  1. Baade P, Carriere P, Fritschi L (2008). Trends in testicular germ cell cancer incidence in Australia. Cancer Causes Control, 19, 1043-9. https://doi.org/10.1007/s10552-008-9168-z
  2. Basiri A, Shakhssalim N, Jalaly NY, et al (2014). Difference in the incidences of the most prevalent urologic cancers from 2003 to 2009 in Iran. Asian Pac J Cancer Prev, 15, 1459-63. https://doi.org/10.7314/APJCP.2014.15.3.1459
  3. Bhatti AB, Ahmed I, Ghauri RK, et al (2014). Clinical profile, treatment and survival outcome of testicular tumors: a Pakistani perspective. Asian Pac J Cancer Prev, 15, 277-80. https://doi.org/10.7314/APJCP.2014.15.1.277
  4. Boyle P, Zaridze DG (1993). Risk factors for prostate and testicular cancer. Eur J Cancer, 29, 1048-55. https://doi.org/10.1016/S0959-8049(05)80222-9
  5. Coogan CL, Foster RS, Simmons GR, et al (1998). Bilateral testicular tumors: management and outcome in 21 patients. Cancer, 83, 547-52. https://doi.org/10.1002/(SICI)1097-0142(19980801)83:3<547::AID-CNCR24>3.0.CO;2-V
  6. Eble JN, Sauter G, Epstein JI, et al (2004). Pathology and genetics of tumours of the urinary system and male genital organs, IARC Press, Lyon.
  7. El-Hsseiny G (2001). Germ cell tumors in undescended testis-Prognostic factors and treatment outcome. J Egyptian Natl Cancer Inst, 13, 209-14.
  8. Ghazarian AA, Trabert B, Devesa SS, et al (2014). Recent trends in the incidence of testicular germ cell tumors in the United States. Andrology, 3, 13-8
  9. Hanna NH, Einhorn LH (2014). Testicular cancer--discoveries and updates. N Engl J Med, 371, 2005-16. https://doi.org/10.1056/NEJMra1407550
  10. Hentrich M, Weber N, Bergsdorf T, et al (2005). Management and outcome of bilateral testicular germ cell tumors: Twentyfive year experience in Munich. Acta Oncol, 44, 529-36. https://doi.org/10.1080/02841860510029923
  11. Holzbeierlein JM, Sogani PC, Sheinfeld J (2003). Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: the Memorial Sloan Kettering Cancer Center experience 1950 to 2001. J Urol, 169, 2122-5. https://doi.org/10.1097/01.ju.0000067462.24562.8b
  12. Horwich A, Nicol D, Huddart R (2013). Testicular germ cell tumours. BMJ, 347, 5526. https://doi.org/10.1136/bmj.f5526
  13. Karki S, Bhatta R (2012). Histopathological analysis of testicular tumors. J Pathol Nepal, 2.
  14. Looijenga LH, Stoop H, Biermann K (2014). Testicular cancer: biology and biomarkers. Virchows Arch, 464, 301-13. https://doi.org/10.1007/s00428-013-1522-1
  15. McGlynn KA, Devesa SS, Sigurdson AJ, et al (2003). Trends in the incidence of testicular germ cell tumors in the United States. Cancer, 97, 63-70. https://doi.org/10.1002/cncr.11054
  16. Miki T, Kamoi K, Fujimoto H, et al (2014). Clinical characteristics and oncological outcomes of testicular cancer patients registered in 2005 and 2008: the first large-scale study from the Cancer Registration Committee of the Japanese Urological Association. Int J Urol, 21, 1-6.
  17. Moller H, Skakkebaek NE (1996). Risks of testicular cancer and cryptorchidism in relation to socio-economic status and related factors: case-control studies in Denmark. Int J Cancer, 66, 287-93. https://doi.org/10.1002/(SICI)1097-0215(19960503)66:3<287::AID-IJC2>3.0.CO;2-V
  18. Mushtaq S, Jamal S, Mamoon N, et al (2007). The pathological spectrum of malignant testicular tumours in northern Pakistan. J Pak Med Assoc, 57, 499-501.
  19. National Cancer Registry (2008) [Online]. Beirut: Lebanese Ministry of Public Health.
  20. Ozgun A, Karagoz B, Tuncel T, et al (2013). Clinicopathological features and survival of young Turkish patients with testicular germ cell tumors. Asian Pac J Cancer Prev, 14, 6889-92. https://doi.org/10.7314/APJCP.2013.14.11.6889
  21. Raiss GG, Andaloussi MM, Raissouni SS, et al (2011). Spermatocytic seminoma at the National Institute of Oncology in Morocco. BMC Res Notes, 4, 218. https://doi.org/10.1186/1756-0500-4-218
  22. Richiardi L, Bellocco R, Adami HO, et al (2004). Testicular cancer incidence in eight northern European countries:secular and recent trends. Cancer Epidemiol Biomarkers Prev, 13, 2157-66.
  23. Ruf CG, Isbarn H, Wagner W, et al (2014). Changes in epidemiologic features of testicular germ cell cancer: age at diagnosis and relative frequency of seminoma are constantly and significantly increasing. Urol Oncol, 32, 33.
  24. Swerdlow AJ, Higgins CD, Pike MC (1997). Risk of testicular cancer in cohort of boys with cryptorchidism. BMJ, 314, 1507-11. https://doi.org/10.1136/bmj.314.7093.1507
  25. Takiar R, Kumar S (2014). Pattern of reproductive cancers in India. Asian Pac J Cancer Prev, 15, 599-603. https://doi.org/10.7314/APJCP.2014.15.2.599
  26. Trabert B, Chen J, Devesa SS, et al (2014). International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973-2007. Andrology, 3, 13-8.
  27. Walschaerts M, Huyghe E, Muller A, et al (2008). Doubling of testicular cancer incidence rate over the last 20 years in southern France. Cancer Causes Control, 19, 155-61. https://doi.org/10.1007/s10552-007-9081-x

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