- Volume 16 Issue 8
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Profile of Skin Biopsies and Patterns of Skin Cancer in a Tertiary Care Center of Western Nepal
- Kumar, Ajay (Department of Dermatology, Manipal College of Medical Sciences) ;
- Shrestha, Prashanna Raj (Department of Dermatology, Manipal College of Medical Sciences) ;
- Pun, Jenny (Department of Dermatology, Manipal College of Medical Sciences) ;
- Thapa, Pratichya (Department of Dermatology, Manipal College of Medical Sciences) ;
- Manandhar, Merina (Department of Dermatology, Manipal College of Medical Sciences) ;
- Sathian, Brijesh (Department of Community Medicine, Manipal College of Medical Sciences)
- Published : 2015.04.29
Background: Skin biopsy is the method to assist clinicians to make definite dermatological diagnosis which further helps in holistic management. Skin cancers are relatively rare clinical diagnosis in developing countries like Nepal, but the prevalence is on rise. Objectives: To investigate the profile of skin biopsies and frequencies and pattern of skin cancers in a tertiary care centre of Western Nepal. Materials and Methods: The materials consisted of 434 biopsies (1.37%) out of 31,450 OPD visits performed in the Department of Dermatology, Manipal Teaching Hospital, Pokhara, Nepal, during the period of Dec 2011-Nov 2014. Data were collected and analyzed using SPSS-16 with reference to incidence, age, sex, race and clinical and histopathological features. Results: The commonest disorders observed in biopsies were papulosquamous lesions, skin tuberculosis of different types, benign skin tumors, leprosy, collagen and fungal diseases. Viral diseases were rarely seen, probably due to straight forward clinical diagnosis. Dermatological malignancies accounted for 55/434 (12.67%) of biopsies. Skin disorders in general were commoner in females 280/434 (64%), including malignancies 32/55(58.2%). Mean age of patients with skin cancer was 54.5 years. Facilities for proper laboratory investigation of dermatological disorders will improve the quality of life. Conclusions: The most prevalent lesion in skin biopsies was papulosquamous disorders followed by skin tuberculosis of different types. Dermatological malignancy constituted 55/434 (12.67%) cases. The prevalence of skin malignancy is on rise in Nepalese society probably due to increase in life expectancy and better diagnostic services.
Clinicopathological correlation;skin biopsy;skin cancer;Nepal
- Adinarayan M, Krishnamurthy SP (2011). Clinicopathological evaluation of nonmelanoma skin cancer. Indian J Dermatol, 56, 670-2. https://doi.org/10.4103/0019-5154.91826
- Agbai ON, Buster K, Sanchez M, et al (2014). Skin cancer and photoprotection in people of color: a review and recommendations for physicians and the public. J Am Acad Dermatol, 70, 748-62. https://doi.org/10.1016/j.jaad.2013.11.038
- Bader RS (2014). History. Presentation. Basal Cell Carcinoma. Medscape. Available from: http://emedicine.medscape.com/article/276624-clinical
- Baldwin L, Dunn J(2013). Global Controversies and Advances in Skin Cancer. Asian Pac J Cancer Prev, 14, 2155-7. https://doi.org/10.7314/APJCP.2013.14.4.2155
- Bellew S, Del Rosso JQ, Kim GK (2009). Skin cancer in Asians: part 2: melanoma. J Clin Aesthet Dermatol, 2, 34-6.
- Byrd-Miles K, Toombs EL, Peck GL (2007). Skin cancer in individuals of African, Asian, Latin-American, and American-Indian descent: differences in incidence, clinical presentation, and survival compared to Caucasians. J Drugs Dermatol, 6, 10-16.
- Ferlay J, Soerjomataram I, Ervik M, et al (2012). GLOBOCAN v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet].
- Lyon, France: International Agency for Research on Cancer;2013. Available from: http://globocan.iarc.fr, accessed on 1/1/2015.
- Gloster H, Neal K(2006). Skin cancer in skin of color. J Am Acad Dermatol, 55, 741-60. https://doi.org/10.1016/j.jaad.2005.08.063
- Khullar G, Saikia UN, De D, Radotra BD (2014). Non melanoma skin cancers: An Indian perspective. Indian J Dermatopathol Diagn Dermatol, 1, 55-62 https://doi.org/10.4103/2349-6029.147282
- Koh D, Wang H, Lee J, et al (2003). Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin:analysis of singapore cancer registry data 1968-97. Br AssocDermatologists, 148, 1161-6.
- Malak AT, Yildirim P, Yildiz Z, Bektas M. (2011). Effects of the training about skin cancer on farmers' knowledge level and attitudes. Asian Pac J Cancer Prev, 12, 117-20
- Mitchell J, Leslie KS (2013). Melanoma death prevention:moving away from the sun. J Am Acad Dermatol, 68, 169-75. https://doi.org/10.1016/j.jaad.2012.09.028
- Pollitt RA, Geller AC, Brooks DR, et al (2009): Efficacy of skin self-examination practices for early melanoma detection. Cancer Epidemiol Biomarkers Prev, 18, 3018-23. https://doi.org/10.1158/1055-9965.EPI-09-0310
- Roberts M (2014). Alcohol linked to skin cancer risk. gorkhapatraonline.com. Available from: http://trn.gorkhapatraonline.com/index.php/about-us/72-sciencetechnology/7181-alcohol-linked-to-skin-cancer-risk.html
- U.S. Preventive Services Task Force (2014). United states preventative services task force 2009 guidelines for skin self-examination and population based screening in asymptomatic persons by primary care physicians. Available from: http://www.uspreventiveservicestaskforce.org/Page/Topic/recommendation-summary/skin-cancer-screening
- Wu XC, Eide MJ, King J, et al (2011). Racial and ethnic variations in incidence and survival of cutaneous melanoma in the United States, 1999-2006. J Am Acad Dermatol, 65, 26-37. https://doi.org/10.1016/j.jaad.2010.12.028
- Yamaguchi Y, Beer J, Hearing V (2008). Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer. Arch Dermatol Res, 300, 43-50. https://doi.org/10.1007/s00403-007-0807-0
- Inhibitory effects of B-cell translocation gene 2 on skin cancer cells via the Wnt/β-catenin signaling pathway vol.14, pp.4, 2016, https://doi.org/10.3892/mmr.2016.5596