- Volume 16 Issue 8
DOI QR Code
Comparative Effectiveness of Risk-adapted Surveillance vs Retroperitoneal Lymph Node Dissection in Clinical Stage I Nonseminomatous Germ Cell Testicular Cancer: A Retrospective Follow-up Study of 81 Patients
- Fan, Gang (Department of Urology, Hunan Provincial Tumor Hospital, The Affiliated Cancer Hospital of Xiangya Medical College, Central South University) ;
- Zhang, Lin (Department of Social Medicine and Health Management, Public Health School, Department of Urology, Central South University) ;
- Yi, Lu (The Second Xiangya Hospital, Central South University) ;
- Jiang, Zhi-Qiang (The Third Xiangya Hospital, Central South University) ;
- Ke, Yang (Hunan Provincial People's Hospital, Central South University) ;
- Wang, Xiao-Shan (Department of Social Medicine and Health Management, Public Health School, Department of Urology, Central South University) ;
- Xiong, Ying-Ying (Department of pathology, Hunan Provincial Tumor Hospital, The Affiliated Cancer Hospital of Xiangya Medical College, Central South University) ;
- Han, Wei-Qin (Department of Urology, Hunan Provincial Tumor Hospital, The Affiliated Cancer Hospital of Xiangya Medical College, Central South University) ;
- Zhou, Xiao (Department of Urology, Hunan Provincial Tumor Hospital, The Affiliated Cancer Hospital of Xiangya Medical College, Central South University) ;
- Liu, Chun (Department of Urology, Hunan Provincial Tumor Hospital, The Affiliated Cancer Hospital of Xiangya Medical College, Central South University) ;
- Yu, Xie (Department of Urology, Hunan Provincial Tumor Hospital, The Affiliated Cancer Hospital of Xiangya Medical College, Central South University)
- Published : 2015.04.29
Purpose: To retrospective assess the potential predictors for relapse and create an effective clinical mode for surveillance after orchidectomy in clinical stage I non-seminomatous germ cell testicular tumors (CSI-NSGCTs). Materials and Methods: We analyzed data for CSI-NSGCTs patients with non-lymphatic vascular invasion, %ECa < 50% (percentage of embryonal carcinoma < 50%), and negative or declining tumor markers to their half-life following orchidectomy (defined as low-risk patients); these patients were recruited from four Chinese centers between January 1999 and October 2013. Patients were divided into active surveillance group and retroperitoneal lymph node dissection (RPLND) group according to different therapeutic methods after radical orchidectomy was performed. The disease-free survival rates (DFSR) and overall survival rates (OSR) of the two groups were compared by Kaplan-Meier analysis. Results: A total of 121 patients with CSI-NSGCT were collected from four centers, and 81 low-risk patients, including 54 with active surveillance and 27 with RPLND, were enrolled at last. The median follow-up duration was 66.2 (range 6-164) months in the RPLND group and 65.9 (range 8-179) months in the surveillance group. OSR was 100% in active surveillance and RPLND groups, and DFSR was 89.8% and 87.0%, respectively. No significant difference was observed between these two groups (
Non-seminomatous germ cell testicular cancer;surveillance;retroperitoneal lymph node dissection
Supported by : Central South University
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