DOI QR코드

DOI QR Code

Investigation of Transition Types of HPV DNA Test Results over Time in Korean Women

  • Ko, Kiwoong (Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kwon, Min-Jung (Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Woo, Hee-Yeon (Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Park, Hyosoon (Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • Published : 2015.04.29

Abstract

Background: Understanding the history of human papilloma virus (HPV) infection is important for interpretation of a positive HPV DNA screening test, future work-up and treatment. We investigated the transition of HPV DNA test results in Korean women, and analyzed the association of cytology result with transition type. Materials and Methods: We retrospectively reviewed annual HPV DNA test results for 5,274 subjects between January 2005 and December 2012. Each subject had a minimum of five annual tests over the eight-year period. Based on the pattern of results, the transition type for each subject was assigned to one of the following: negative, persistent, latent, transient, and unclassifiable. Associations of cytology results with the HPV DNA transition types, number of positive results, and the durations of positive results were also analyzed. Results: The proportion of abnormal cytology findings decreased in the following order of transition patterns: persistent, latent, transient, and negative. Among transient patterns, a duration of three years or more significantly correlated with cytology results of non-high grade squamous intraepithelial lesion (HSIL; p<0.001). In the persistent group, duration of five years or more correlated with both non-HSIL and HSIL (p<0.001). Latent group showed no correlation with duration. Irrespective of patterns, having five or more positive results was significantly associated with HSIL (p<0.001). Conclusions: Our findings may contribute to better understanding of HPV infection, interpretation of HPV DNA screening results, and prediction of prognosis according to transition type.

Keywords

HPV;Korean women;pattern;screening test;transition

References

  1. Bosch FX, Burchell AN, Schiffman M, et al (2008). Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia. Vaccine, 26, 1-16.
  2. Brown DR, Shew ML, Qadadri B, et al (2005). A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women. J Infect Dis, 191, 182-92. https://doi.org/10.1086/426867
  3. Castellsague X (2008). Natural history and epidemiology of HPV infection and cervical cancer. Gynecol Oncol, 110, 4-7. https://doi.org/10.1016/j.ygyno.2008.07.045
  4. Castellsague X, Munoz N (2003). Chapter 3: cofactors in human papillomavirus carcinogenesis-role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr, 20-8.
  5. Clavel C, Masure M, Levert M, et al (2000). Human papillomavirus detection by the hybrid capture II assay: a reliable test to select women with normal cervical smears at risk for developing cervical lesions. Diagn Mol Pathol, 9, 145-50. https://doi.org/10.1097/00019606-200009000-00004
  6. Clifford GM, Gallus S, Herrero R, et al (2005). Worldwide distribution of human papillomavirus types in cytologically normal women in the international agency for research on cancer HPV prevalence surveys: a pooled analysis. Lancet, 366, 991-8. https://doi.org/10.1016/S0140-6736(05)67069-9
  7. Cuschieri KS, Whitley MJ, Cubie HA (2004). Human papillomavirus type specific DNA and RNA persistenceimplications for cervical disease progression and monitoring. J Med Virol, 73, 65-70. https://doi.org/10.1002/jmv.20062
  8. Elfgren K, Kalantari M, Moberger B, et al (2000). A populationbased five-year follow-up study of cervical human papillomavirus infection. Am J Obstet Gynecol, 183, 561-7. https://doi.org/10.1067/mob.2000.106749
  9. Evander M, Edlund K, Gustafsson A, et al (1995). Human papillomavirus infection is transient in young women: a population-based cohort study. J Infect Dis, 171, 1026-30. https://doi.org/10.1093/infdis/171.4.1026
  10. Giuliano AR, Sedjo RL, Roe DJ, et al (2002). Clearance of oncogenic human papillomavirus (HPV) infection: effect of smoking (United States). Cancer Causes Control, 13, 839-46. https://doi.org/10.1023/A:1020668232219
  11. Giuliano AR, Siegel EM, Roe DJ, et al (2003). Dietary intake and risk of persistent human papillomavirus (HPV) infection: the ludwig-McGill HPV natural history study. J Infect Dis, 188, 1508-16. https://doi.org/10.1086/379197
  12. Gravitt PE (2011). The known unknowns of HPV natural history. J Clin Invest, 121, 4593-9. https://doi.org/10.1172/JCI57149
  13. Ho GY, Bierman R, Beardsley L, et al (1998). Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med, 338, 423-8. https://doi.org/10.1056/NEJM199802123380703
  14. Insinga RP, Perez G, Wheeler CM, et al (2010). Incidence, duration, and reappearance of type-specific cervical human papillomavirus infections in young women. Cancer Epidemiol Biomarkers Prev, 19, 1585-94. https://doi.org/10.1158/1055-9965.EPI-09-1235
  15. Jensen KE, Schmiedel S, Frederiksen K, et al (2012). Risk for cervical intraepithelial neoplasia grade 3 or worse in relation to smoking among women with persistent human papillomavirus infection. Cancer Epidemiol Biomarkers Prev, 21, 1949-55. https://doi.org/10.1158/1055-9965.EPI-12-0663
  16. Johnson DC, Bhatta MP, Gurung S, et al (2014). Knowledge and awareness of human papillomavirus (HPV), cervical cancer and HPV vaccine among women in two distinct Nepali communities. Asian Pac J Cancer Prev, 15, 8287-93. https://doi.org/10.7314/APJCP.2014.15.19.8287
  17. Khunamornpong S, Settakorn J, Sukpan K, et al (2014). Performance of HPV DNA testing with hybrid capture 2 in triaging women with minor cervical cytologic abnormalities (ASC-US/LSIL) in Northern Thailand. Asian Pac J Cancer Prev, 15, 10961-6.
  18. Kwang NB, Yee CM, Shan LP, et al (2014). Knowledge, perception and attitude towards human papillomavirus among pre-university students in Malaysia. Asian Pac J Cancer Prev, 15, 9117-23. https://doi.org/10.7314/APJCP.2014.15.21.9117
  19. Massad LS, Einstein MH, Huh WK, et al (2013). 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis, 17, 1-27.
  20. Nessa A, Rashid MH, Jahan M, et al (2014). Role of the HPV DNA test in follow-up of treated cervical intraepithelial neoplasia in Bangladesh. Asian Pac J Cancer Prev, 15, 8063-7. https://doi.org/10.7314/APJCP.2014.15.19.8063
  21. Pandey S, Mishra M, Chandrawati (2012). Human papillomavirus screening in north Indian women. Asian Pac J Cancer Prev, 13, 2643-6. https://doi.org/10.7314/APJCP.2012.13.6.2643
  22. Rai AK, Das D, Kataki AC, et al (2014). Hybrid capture 2 assay based evaluation of high-risk HPV status in healthy women of north-east India. Asian Pac J Cancer Prev, 15, 861-5. https://doi.org/10.7314/APJCP.2014.15.2.861
  23. Stanley M (2010). Pathology and epidemiology of HPV infection in females. Gynecol Oncol, 117, 5-10. https://doi.org/10.1016/j.ygyno.2010.01.024
  24. Theiler RN, Farr SL, Karon JM, et al (2010). High-risk human papillomavirus reactivation in human immunodeficiency virus-infected women: risk factors for cervical viral shedding. Obstet Gynecol, 115, 1150-8. https://doi.org/10.1097/AOG.0b013e3181e00927
  25. Wang YY, Li L, Wei S, et al (2013). Human papillomavirus (HPV) infection in women participating in cervical cancer screening from 2006 to 2010 in Shenzhen City, South China. Asian Pac J Cancer Prev, 14, 7483-7. https://doi.org/10.7314/APJCP.2013.14.12.7483
  26. Woodman CB, Collins S, Winter H, et al (2001). Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet, 357, 1831-6. https://doi.org/10.1016/S0140-6736(00)04956-4
  27. Woodman CB, Collins SI, Young LS (2007). The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer, 7, 11-22. https://doi.org/10.1038/nrc2050