Accuracy of Endoscopic Ultrasonography for Determination of Tumor Invasion Depth in Gastric Cancer

  • Razavi, Seyed Mohsen (Hematology and Oncology Department, Iran University of Medical Sciences) ;
  • Khodadost, Mahmoud (Department of Epidemiology, Faculty of Public health, Shahid Beheshti University of Medical Sciences) ;
  • Sohrabi, Masoudreza (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Keshavarzi, Azam (Hematology and Oncology Department, Iran University of Medical Sciences) ;
  • Zamani, Farhad (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Rakhshani, Naser (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Ameli, Mitra (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Sadeghi, Reza (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Hatami, Khadijeh (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Ajdarkosh, Hossein (Gastrointestinal and Liver Diseases Research Centre, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Golmahi, Zeynab (Aging Research Center, Sabzevar University of Medical Sciences and Health Services) ;
  • Ranjbaran, Mehdi (Department of Epidemiology, Faculty of Health, Arak University of Medical Sciences)
  • Published : 2015.04.29


Background: Gastric cancer (GC) is one the common lethal cancers in Iran. Detection of GC in the early stages would assesses to improve the survival of patients. In this study, we attempt to evaluate the accuracy of EUS in detection depth of invasion of GC among Iranian Patients. Materials and Methods: This study is a retrospective study of patients with pathologically confirmed GC. They underwent EUS before initiating the treatment. The accuracy of EUS and agreement between the two methods was evaluated by comparing pre treatment EUS finding with post operative histopathological results. Results: The overall accuracy of EUS for T and N staging was 67.9% and 75.47, respectively. Underestimation and overestimation was seen in 22 (14.2%) and 40 (25.6%) respectively. The EUS was more accurate in large tumors and the tumors located in the middle and lower parts of the stomach. The EUS was more sensitive in T3 staging. The values of weighted Kappa from the T and N staging were 0.53 and 0.66, respectively. Conclusions: EUS is a useful modality for evaluating the depth of invasion of GC. The accuracy of EUS was higher if the tumor was located in the lower parts of the stomach and the size of the tumor was more than 3 cm. Therefore, judgments made upon other criteria evaluated in this study need to be reconsidered.


Endoscopic ultrasonography;accuracy;gastric cancer;agreement;tumor staging


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