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Genetic Variants in ASCT2 Gene are Associated with the Prognosis of Transarterial Chemoembolisation-Treated Early-Stage Hepatocelluar Carcinoma

  • Ge, Nai-Jian (Department of Radioactive Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University) ;
  • Shi, Zhi-Yong (Department of Radioactive Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University) ;
  • Yu, Xiao-He (Department of Radioactive Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University) ;
  • Huang, Xiao-Jun (State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, Fourth Military Medical University) ;
  • Wu, You-Sheng (State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, Fourth Military Medical University) ;
  • Chen, Yuan-Yuan (Department of Ophthalmology, First People of Yulin) ;
  • Zhang, Jin (State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic Medicine, Fourth Military Medical University) ;
  • Yang, Ye-Fa (Department of Radioactive Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University)
  • Published : 2015.05.18

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Transarterial chemoembolisation (TACE) is the standardized therapy for intermediate stage HCC. However, the prognosis for HCC patients treated by TACE greatly varies. Thus, there is a critical need for finding biomarkers to predict the prognosis of HCC patients. The amino acid transporter-2 (ASCT2) is involved in tumorigenesis and progression of many malignancies. This study aimed to evaluate the predictive role of two single nuclear polymorphisms (SNPs, rs3826793 and rs2070246) in the ASCT2 gene in HCC patients treated by TACE. Materials and Methods: Two functional SNPs (rs3826793 and rs2070246) in the ASCT2 gene were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 448 unresectable Chinese HCC patients treated by TACE. Univariate and multivariate Cox proportional hazards models and Kaplan-Meier curves were used for the prognosis analyses. Results: There was no significant association between two SNPs (rs3826793 and rs2070246) in the ASCT2 gene and overall survival of TACE treated HCC patients. However, we demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype (P=0.023). Conclusions: We demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype.

Keywords

Hepatocellular carcinoma;ASCT2 gene;association study;prognosis;transarterial chemoembolisation

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