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Pemetrexed in Treating Patients with Metastatic Bladder Cancer

  • Li, Qing (Department of Urology, The Fourth Affiliated Hospital of Harbin Medical University) ;
  • Li, Jian-Zhang (Department of Urology, The Fourth Affiliated Hospital of Harbin Medical University) ;
  • Xu, Wan-Hai (Department of Urology, The Fourth Affiliated Hospital of Harbin Medical University) ;
  • Gao, Lin (Department of Urology, The Fourth Affiliated Hospital of Harbin Medical University)
  • Published : 2015.05.18

Abstract

Background: This pooled analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic bladder cancer as salvage chemotherapy. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with bladder cancer were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In pemetrexed based regimens, 3 clinical studies which including 105 patients with advanced transitional cell cancer of the urothelium were considered eligible for inclusion. Pooled analysis suggested that, in all patients, pooled RR was 26.7% (28/105) for pemetrexed based regimens. Major adverse effects were neutropenia, anorexia, fatigue, and anemia in pemetrexed based treatment. Two treatment related deaths occurred with pemetrexed based treatment. Conclusion: This pooled analysis suggests that pemetrexed based regimens are associated with mild activity and good tolerability in treating patients with metastatic bladder cancer.

Keywords

Pemetrexed;metastatic bladder cancer

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  1. Evolving Treatment of Advanced Urothelial Cancer vol.13, pp.5, 2017, https://doi.org/10.1200/JOP.2017.022137