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Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection

  • Zhou, Hang ;
  • Li, Xiong ;
  • Zhang, Yuan ;
  • Jia, Yao ;
  • Hu, Ting ;
  • Yang, Ru ;
  • Huang, Ke-Cheng ;
  • Chen, Zhi-Lan ;
  • Wang, Shao-Shuai ;
  • Tang, Fang-Xu ;
  • Zhou, Jin ;
  • Chen, Yi-Le ;
  • Wu, Li ;
  • Han, Xiao-Bing ;
  • Lin, Zhong-Qiu ;
  • Lu, Xiao-Mei ;
  • Xing, Hui ;
  • Qu, Peng-Peng ;
  • Cai, Hong-Bing ;
  • Song, Xiao-Jie ;
  • Tian, Xiao-Yu ;
  • Zhang, Qing-Hua ;
  • Shen, Jian ;
  • Liu, Dan ;
  • Wang, Ze-Hua ;
  • Xu, Hong-Bing ;
  • Wang, Chang-Yu ;
  • Xi, Ling ;
  • Deng, Dong-Rui ;
  • Wang, Hui ;
  • Lv, Wei-Guo ;
  • Shen, Keng ;
  • Wang, Shi-Xuan ;
  • Xie, Xing ;
  • Cheng, Xiao-Dong ;
  • Ma, Ding ;
  • Li, Shuang
  • Published : 2015.05.18

Abstract

Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.

Keywords

Cervical cancer;nomogram;clinicopathologic factor

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