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Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma

  • Jin, Ye (Clinical Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College) ;
  • Zhou, Li (Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College) ;
  • Liang, Zhi-Yong (Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College) ;
  • Jin, Ke-Min (Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Hepatobiliary Surgery I, Peking University School of Oncology, Beijing Cancer Hospital & Institute) ;
  • Zhou, Wei-Xun (Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College) ;
  • Xing, Bao-Cai (Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Hepatobiliary Surgery I, Peking University School of Oncology, Beijing Cancer Hospital & Institute)
  • Published : 2015.05.18

Abstract

Background: Many factors, including molecular ones, were demonstrated to be associated with long-term prognosis of hepatocellular carcinoma (HCC). Thus far, the expression and clinicopathologic and prognostic significance of the carboxyl terminus of Hsp70-interacting protein (CHIP) in B-type hepatitis virus (HBV)-related HCC remain unknown. Materials and Methods: CHIP expression was detected by immunohistochemical staining of surgical samples from 79 patients with HCC with HBsAg positivity. In addition, correlations with clinicopathologic parameters and patient survival were evaluated. Results: It was found that positive CHIP staining was observed in tumor, but not non-tumor, tissues. High expression of CHIP was significantly related to larger tumor size, with marginally significant associations noted for presence of portal vein invasion and higher serum a-fetoprotein level. In addition, univariate analysis showed that high CHIP expression was a powerful predictor for dismal overall and disease-free survival. However, independent prognostic implications of CHIP were not proven in multivariate Cox regression test. Conclusions: CHIP is overexpressed in HBV-related HCC and is associated with unfavorable biological behavior as well as poor prognosis. However, its prognostic role needs to be further validated.

Keywords

Carboxyl terminus of Hsp70-interacting protein;B-type hepatitis virus related hepatocellular carcinoma

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