Emerging Roles of Krüppel-Like Factor 4 in Cancer and Cancer Stem Cells

  • Ding, Bo (Department of Orthodontics, School of Stomatology, Shandong University) ;
  • Liu, Ping (Department of Orthodontics, Jinan Stomatological Hospital) ;
  • Liu, Wen (Department of Stomatology, Qingdao Municipal Hospital) ;
  • Sun, Ping (Obstetrical Department, Qingdao Central Hospital) ;
  • Wang, Chun-Ling (Department of Orthodontics, School of Stomatology, Shandong University)
  • Published : 2015.05.18


Cancer stem cells (CSCs) are rare subpopulations within tumors which are recognized as culprits in cancer recurrence, drug resistance and metastasis. However, the molecular mechanisms of how CSCs are regulated remain elusive. Kr$\ddot{u}$ppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse functions in cell differentiation, proliferation, embryogenesis and pluripotency. Recent progress has highlighted the significance of KLFs, especially KLF4, in cancer and CSCs. Therefore, for better therapeutics of cancer disease, it is crucial to develop a deeper understanding of the mechanisms of how KLF4 regulate CSC functions. Herein we summarized the current understanding of the transcriptional regulation of K LF4 in CSCs, and discussed the functional implications of targeting CSCs for potential cancer therapeutics.


Kruppel-like factor 4;cancer;cancer stem cells;cancer therapy


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