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A new function of glucocorticoid receptor: regulation of mRNA stability

  • Park, Ok Hyun (Division of Life Sciences, Korea University) ;
  • Do, Eunjin (Division of Life Sciences, Korea University) ;
  • Kim, Yoon Ki (Division of Life Sciences, Korea University)
  • Received : 2015.07.02
  • Published : 2015.07.31

Abstract

It has long been thought that glucocorticoid receptor (GR) functions as a DNA-binding transcription factor in response to its ligand (a glucocorticoid) and thus regulates various cellular and physiological processes. It is also known that GR can bind not only to DNA but also to mRNA; this observation points to the possible role of GR in mRNA metabolism. Recent data revealed a molecular mechanism by which binding of GR to target mRNA elicits rapid mRNA degradation. GR binds to specific RNA sequences regardless of the presence of a ligand. In the presence of a ligand, however, the mRNA-associated GR can recruit PNRC2 and UPF1, both of which are specific factors involved in nonsense-mediated mRNA decay (NMD). PNRC2 then recruits the decapping complex, consequently promoting mRNA degradation. This mode of mRNA decay is termed "GR-mediated mRNA decay" (GMD). Further research demonstrated that GMD plays a critical role in chemotaxis of immune cells by targeting CCL2 mRNA. All these observations provide molecular insights into a previously unappreciated function of GR in posttranscriptional regulation of gene expression. [BMB Reports 2015; 48(7): 367-368]

Keywords

Glucocorticoid receptor;mRNA decay;PNRC2;UPF1;Chemotaxis

Acknowledgement

Grant : KU 생명과학 창의인재양성사업단

Cited by

  1. Glucocorticoid receptor action in metabolic and neuronal function vol.6, 2017, https://doi.org/10.12688/f1000research.11375.1
  2. Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors vol.19, pp.8, 2018, https://doi.org/10.3390/ijms19082210