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Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

  • Du, Yong (State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-sen University Cancer Center) ;
  • Yan, Shu-Mei (Department of Pathology, Sun Yat-sen University Cancer Center) ;
  • Gu, Wan-Yi (Department of Pathology, The Fourth Affiliated Hospital of Guangzhou Medical College, Sun Yat-sen University) ;
  • He, Fan (Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University) ;
  • Huang, Li-Yun (Department of Pathology, Sun Yat-sen University Cancer Center) ;
  • Li, Mei (Department of Pathology, Sun Yat-sen University Cancer Center) ;
  • Yuan, Yan (Section 3 of Internal Medicine, The Affiliated Tumor Hospital of Guangzhou Medical University) ;
  • Chen, Ren-Hui (Department of Head and Neck Surgery, The Second Affiliated Hospital, Sun Yat-sen University) ;
  • Zhong, Qian (State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-sen University Cancer Center) ;
  • Li, Man-Zhi (State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-sen University Cancer Center) ;
  • Li, Yong (Department of Pathology, Sun Yat-sen University Cancer Center) ;
  • Zeng, Mu-Sheng (State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat-sen University Cancer Center)
  • Published : 2015.07.13

Abstract

FADS1 (fatty acid desaturase 1) plays a crucial role in fatty acid metabolism, and it was recently reported to be involved in tumorigenesis. However, the role of FADS1 expression in esophageal squamous cell carcinoma (ESCC) remains unknown. In the current study, we investigated the expression and clinical pathologic and prognostic significance of FADS1 in ESCC. Immunohistochemical analyses revealed that 58.2% (146/251) of the ESCC tissues had low levels of FADS1 expression, whereas 41.8% (105/251) exhibited high levels of FADS1 expression. In positive cases, FADS1 expression was detected in the cytoplasm of cells. Correlation analyses demonstrated that FADS1 expression was significantly correlated with tumor location (p=0.025) but not with age, gender, histological grade, tumor status, nodal status or TNM staging. Furthermore, patients with tumors expressing high levels of FADS1had a longer disease-free survival time (p<0.001) and overall survival time (p <0.001). Univariate and multivariate analyses revealed that, along with nodal status, FADS1 expression was an independent and significant predictive factor (p<0.001). In conclusion, our study suggested that FADS1 might be a valuable biomarker and potential therapeutic target for ESCC.

Keywords

FADS1;Esophageal squamous cell carcinoma;prognosis;survival

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