- Volume 16 Issue 12
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Immunohistochemical Profile of Breast Cancer Patients at a Tertiary Care Hospital in New Delhi, India
- Doval, Dinesh Chandra (Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Sharma, Anila (Department of Laboratory Services, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Sinha, Rupal (Department of Research, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Kumar, Kapil (Department of Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Dewan, Ajay Kumar (Department of Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Chaturvedi, Harit (Department of Surgical Oncology, MAX Hospital) ;
- Batra, Ullas (Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Talwar, Vineet (Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Gupta, Sunil Kumar (Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Singh, Shailendra (Auriga Life Sciences) ;
- Bhole, Vidula (Episolutions Consultancy Services) ;
- Mehta, Anurag (Department of Laboratory Services, Rajiv Gandhi Cancer Institute & Research Centre)
- Published : 2015.07.13
Background: To assess the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor-2 (HER2) neu receptor in breast cancer and their associations with various clinicopathological characteristics. Materials and Methods: This is a retrospective analysis of women who presented with primary, unilateral breast cancer in the Department of Medical Oncology at Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India during the period from January 2008 to December 2011. Data were retrieved from the medical records of the hospital including both early and locally advanced cancer cases. ER, PgR and HER2neu expression in these patients was assessed and triple negative patients were identified. Associations of triple negative and non-triple negative groups with clinicopathological characteristics were also evaluated. Results: A total of 1,284 women (mean age 52.1 years, 41.9% premenopausal) were included in the analysis. Hormone receptor positivity (ER and/or PgR) was seen in 63.4% patients, while 23.8% of tumors were triple negative. Only 23.0% were HER2 positive. Around 10.0% of tumors were both ER and HER2 positive. ER and PgR positivity was significantly associated with negative HER2 status (p-value <0.0001). Younger age, premenopausal status, higher tumor grade, lymph node negativity, advanced cancer stage, and type of tumor were strongly associated with triple negativity. Significantly, a smaller proportion of women had ductal carcinoma in situ in the triple negative group compared with the non-triple negative group (35.6% versus 60.8%, p-value<0.01). Conclusions: The present analysis is one of the largest studies from India. The majority of the Indian breast cancer patients seen in our hospital present with ER and PgR positive tumors. The triple negative patients tended to be younger, premenopausal, and were associated with higher tumor grades, negative lymph nodes status and lower frequency of ductal carcinoma in situ.
Breast cancer;immunohistochemistry;hormone receptors;India
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