DOI QR코드

DOI QR Code

Properties of Synchronous Versus Metachronous Bilateral Breast Carcinoma with Long Time Follow Up

  • Eliyatkin, Nuket (Pathology, Faculty of Medicine, Adnan Menderes University) ;
  • Zengel, Baha (General Surgery, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) ;
  • Yagci, Ayse (Pathology, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) ;
  • Comut, Erdem (Pathology, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) ;
  • Postaci, Hakan (Pathology, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) ;
  • Uslu, Adam (General Surgery, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) ;
  • Aktas, Safiye (Basic Oncology Institute of Oncology, Dokuz Eylul University)
  • Published : 2015.07.13

Abstract

Background: Breast cancer is the most common cancer type among women with increasing incidence rates, improved prognosis and survival. According to the localization of the tumor, breast cancer is designated as unilateral (UBC) or bilateral (BBC). BBC can be classified as synchronous (SBBC) or metachronous (MBBC) based on the time interval between the diagnosis of the first and the secondary tumors. According to the guideline of WHO 2012, BBC is generally defined as SBBC when contralateral breast carcinoma is diagnosed within 3 months. The aim of this study was to compare the characteristics and patterns of metastasis of BBC patients with UBC. Materials and Methods: A cohort of 768 patients with breast cancer treated at the Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital between 1976 and 2012 were studied. Survival analysis was performed comparing UBC and BBC patients. In addition, evaluations were performed in patients with SBBC and MBBC sub-groups. We used a 3-months interval to distinguish metachronous from synchronous. Results: When clinical and histopathological parameters were statistically evaluated, ER status, event-free and overall survival were found to be significant between UBC and BBC patients. In comparison of SBBC and MBBC patients, age, histological type of tumor, event-free and overall survival were found to be significant. Conclusions: BBC cases were found to show worse prognosis than UBC cases. Among BBC, SBBC had the worst prognosis based on overall survival rates.

Keywords

Bilateral breast cancer;unilateral breast cancer;metachronous;synchronous

References

  1. Baykara M, Ozturk SC, Buyukberber S, et al (2012). Clinicopathological Features in Bilateral Breast Cancer. Asian Pac J Cancer Prev, 13, 4571-5. https://doi.org/10.7314/APJCP.2012.13.9.4571
  2. Chen SF, Du CW, P. Yang, et al (2013). The molecular and clinicopathologic characteristics of bilateral breast cancer. Sci Rep, 3, 2590. https://doi.org/10.1038/srep02590
  3. Chen Y, Thompson W, Semenciw R, Mao Y (1999). Epidemiology of contralateral breast cancer. Cancer Epidemiol Biomarkers Prev, 8, 855-61.
  4. Hartman M, Czene K, Reilly M, et al (2007). Incidence and prognosis of synchronous and metachronous bilateral breast cancer. J Clin Oncol, 25, 4210-6. https://doi.org/10.1200/JCO.2006.10.5056
  5. Holm M, Tjonneland A, Balslev E, Kroman N (2014). Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. Breast Cancer Res Treat, 146, 461-75. https://doi.org/10.1007/s10549-014-3045-0
  6. Huo D, Melkonian S, Rathouz PJ, Khramtsov A, Olopade OI (2011). Concordance in histological and biological parameters between first and second primary breast cancers. Cancer, 117, 907-15. https://doi.org/10.1002/cncr.25587
  7. Ibrahim NY, Sroor MY, Darwish DO (2015). Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. Asian Pac J Cancer Prev, 16, 1007-10. https://doi.org/10.7314/APJCP.2015.16.3.1007
  8. Irvine T, Allen DS, Gillett C, Hamed H, Fentiman IS (2009). Prognosis of synchronous bilateral breast cancer. Br J Surg, 96, 376-80. https://doi.org/10.1002/bjs.6553
  9. Schwentner L, Wolters R, Wischnewsky M, Kreienberg R, Wockel A (2012 ). Survival of patients with bilateral versus unilateral breast cancer and impact of guideline adherent adjuvant treatment: a multi-centre cohort study of 5292 patients. Breast, 21, 171. https://doi.org/10.1016/j.breast.2011.09.007
  10. Senkus E, Szade J, Pieczynska B, et al (2014). Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair-matched immunohistochemical analysis aimed at intrinsic tumor phenotype. Pathol Int, 64, 508-17. https://doi.org/10.1111/pin.12202
  11. Shi YX, Xia Q, Peng RJ, et al (2012). Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer. J Cancer Res Clin Oncol, 138, 705. https://doi.org/10.1007/s00432-011-1141-7
  12. Yoshimura N, Murakami S, Kaneko M, et al (2013). Synchronous bilateral solid papillary carcinomas of the breast. Case Rep Surg, 2013, 812129.

Cited by

  1. Clinical Characteristics and Prognosis Associated with Multiple Primary Cancers in Breast Cancer Patients vol.21, pp.1, 2018, https://doi.org/10.4048/jbc.2018.21.1.62
  2. Is contralateral breast ultrasound worthwhile in preoperative staging of breast cancer? pp.1097-0096, 2019, https://doi.org/10.1002/jcu.22693