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Preventive Effects of Aspirin on Cardiovascular Complications in Prostate Cancer Cases after Endocrinotherapy

  • Li, Xiao-Xia (Intensive Care Unit, Zhumadian Central Hospital) ;
  • Zhang, Yong-Gang (Intensive Care Unit, Zhumadian Central Hospital) ;
  • Wang, Dong (Intensive Care Unit, Zhumadian Central Hospital) ;
  • Chen, Yun-Fang (Department of Oncology, Zhumadian Central Hospital) ;
  • Shan, Yan-Hua (Intensive Care Unit, Zhumadian Central Hospital)
  • Published : 2015.07.13

Abstract

Objective: To explore the preventive effect of aspirin on the cardiovascular complications in prostate cancer after endocrinotherapy. Materials and Methods: A total of 92 patients with prostate cancer were divided into observation group (n=44) and control group (n=48). The control group was treated with medical castration plus anti-androgenic drugs. Based on the above treatment, the observation group was added aspirin. The follow-up duration was 2 years. The changes of partial prothrombin time (PT), activated partial thromboplastin time (APTT), platelet aggregation rate (PAG), prostate-specific antigen (PSA) and serum testosterone (T) before and after treatment as well as incidence of cardiovascular disease were observed. Results: The 2-year survival rates of patients without cardiovascular disease in observation group and control group were 95.45% (42/44) and 72.92% (35/48), respectively, and significant difference was presented between two groups by comparison to the survival rates ($x^2=8.5453$, p=0.0035). There was no statistical significance between two groups as well as before and after treatment regarding PT (p>0.05). After treatment, APTT went down and PAG was gradually on the rise in control group, while PAG down and APTT on the rise increasingly in observation group. Significant differences were presented between two groups as well as before and after treatment (p<0.01). Both PSA and T levels were decreased significantly in two groups after treatment (p<0.01), but there was no statistical significant between two groups (p>0.05). Conclusions: Application of endocrinotherapy in prostate cancer can easily lead to occurrence of cardiovascular disease, but cardiovascular complications can be prevented by aspirin, without affecting the effect of endocrinotherapy.

Keywords

Prostate cancer;endocrinotherapy;cardiovascular disease;side effects;aspirin

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  1. Cardiovascular and Metabolic Effects of Androgen-Deprivation Therapy for Prostate Cancer vol.14, pp.10, 2018, https://doi.org/10.1200/JOP.18.00178