DOI QR코드

DOI QR Code

Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer

  • Karateke, Atilla (Hatay Goverment Hospital, Department of Obstetric and Gynecology) ;
  • Kaplanoglu, Mustafa (Adiyaman University, School of Medicine, Department of Obstetrics and Gynecology Medicine) ;
  • Baloglu, Ali (Private Cinarli Gynecology Hospital)
  • Published : 2015.07.13

Abstract

Background: Platelets are blood elements thought to play a role in the immune system and therefore tumor development and metastasis. Platelet activation parameters such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) can be easily evaluated with the whole blood count and have been studied as markers of systemic inflammatory responses in various cancer types. Our aim in this study was to evaluate the correlation between endometrial pathologies and MPV, PDW and PCT. Materials and Methods: A total of 194 patients who presented to our clinic with abnormal vaginal bleeding were included in our study. The patients were divided into 3 groups (endometrial hyperplasia, endometrial cancer, control) according to their pathology results. The groups were compared for MPV, PDW, and PCT values obtained from the blood samples taken on endometrial biopsy day. Results: The endometrial cancer patients were the oldest group (p=0.04). There was no significant difference between the three groups in terms of white blood cell count (WBC), platelet count (PC), and hemoglobin (Hb) level. The highest MPV (p<0.001), PDW (p=0.002), and PCT (p<0.001) levels were in the endometrial cancer group, and the lowest levels were in the control group. Conclusions: The easy evaluation of platelet parameters in patients who are suspected of having endometrial pathology is a significant advantage. We found MPV, PDW, and PCT to be correlated with the severity of endometrial pathology with the highest values in endometrial cancer. Studies to be conducted together with different laboratory parameters will further help evaluate the diagnosis and severity of endometrial cancer and precursor lesions.

Keywords

Platelet indices;endometrial cancer;endometrial hyperplasia

References

  1. Acmaz G, Aksoy H, Unal D, et al (2014). Are neutrophil/lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding? Asian Pac J Cancer Prev, 15, 1689-92 https://doi.org/10.7314/APJCP.2014.15.4.1689
  2. Anglesio MS, George J, Kulbe H, et al (2011). IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clin Cancer Res, 17, 2538-48. https://doi.org/10.1158/1078-0432.CCR-10-3314
  3. Babu SN, Chetal G, Kumar S (2012). Macrophage migration inhibitory factor: a potential marker for cancer diagnosis and therapy. Asian Pac J Cancer Prev, 13, 1737-44. https://doi.org/10.7314/APJCP.2012.13.5.1737
  4. Cho J, Kennedy DR, Lin L, et al (2012). Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of ${\beta}3$ integrins. Blood, 120, 647-55 https://doi.org/10.1182/blood-2011-08-372532
  5. Dardik R, Kaufmann Y, Savion N, et al (1997). Platelets mediate tumor cell adhesion to the subendothelium under flow conditions: involvement of platelet GPIIb-IIIa and tumor cell alpha (v) integrins. Int J Cancer, 70, 201-7. https://doi.org/10.1002/(SICI)1097-0215(19970117)70:2<201::AID-IJC11>3.0.CO;2-L
  6. Hanahan D, Weinberg RA (2011). Hallmarks of cancer: the next generation. Cell, 144, 646-74 https://doi.org/10.1016/j.cell.2011.02.013
  7. Karpatkin S, Pearlstein E (1981). Role of platelets in tumor cell metastases. Ann Intern Med, 95, 636-41 https://doi.org/10.7326/0003-4819-95-5-636
  8. Kemal Y, Yucel I, Ekiz K, et al (2014) Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev, 15, 2651-4. https://doi.org/10.7314/APJCP.2014.15.6.2651
  9. Kokcu A, Kurtoglu E, Celik H, et al (2014). May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev, 15, 9781-4. https://doi.org/10.7314/APJCP.2014.15.22.9781
  10. Leader A, Pereg D, Lishner M (2012). Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med, 44, 805-16. https://doi.org/10.3109/07853890.2011.653391
  11. Mantovani A, Allavena P, Sica A, Balkwill F (2008). Cancer-related inflammation. Nature, 454, 436-44. https://doi.org/10.1038/nature07205
  12. Ma X, Wang Y, Sheng H, et al (2014). Prognostic significance of thrombocytosis, platelet parameters and aggregation rates in epithelial ovarian cancer. J Obstet Gynaecol Res, 40, 178-83. https://doi.org/10.1111/jog.12151
  13. Stone RL, Nick AM, McNeish IA, et al (2012). Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med, 366, 610-8. https://doi.org/10.1056/NEJMoa1110352
  14. Topcu HO, Guzel AI, Ozer I, et al (2014). Comparison of neutrophil/lymphocyte and platelet/ lymphocyte ratios for predicting malignant potential of suspicious ovarian masses in gynecology practice. Asian Pac J Cancer Prev, 15, 6239-41. https://doi.org/10.7314/APJCP.2014.15.15.6239
  15. Tuszynski GP, Nicosia RF (1996). The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 18, 71-6. https://doi.org/10.1002/bies.950180113
  16. Unal D, Eroglu C, Kurtul N, et al (2013). Are neutrophil/lymphocyte and platelet/lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev, 14, 5237-42. https://doi.org/10.7314/APJCP.2013.14.9.5237
  17. Ural UM, Sehitoglu I, Tekin YB, Sahin FK (2014). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer. J Obstet Gynaecol Res, 41, 445-8.

Cited by

  1. Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer vol.17, pp.4, 2016, https://doi.org/10.7314/APJCP.2016.17.4.2321
  2. Evaluation of complete blood count parameters to predict endometrial cancer vol.32, pp.6, 2018, https://doi.org/10.1002/jcla.22438