Effect of Pretreatment with Lactobacillus delbrueckii and Streptococcus thermophillus on Tailored Triple Therapy for Helicobacter pylori Eradication: A Prospective Randomized Controlled Clinical Trial

  • Tongtawee, Taweesak (Department of Surgery, Institute of Medicine, Suranaree University of Technology) ;
  • Dechsukhum, Chavaboon (Pathological Unit, Institute of Medicine, Suranaree University of Technology) ;
  • Leeanansaksiri, Wilairat (Parasite Research Unit, Institute of Science, Suranaree University of Technology) ;
  • Kaewpitoon, Soraya (Family Medicine and Community Medicine, Suranaree University of Technology) ;
  • Kaewpitoon, Natthawut (Parasite Research Unit, Institute of Science, Suranaree University of Technology) ;
  • Loyd, Ryan A (Family Medicine and Community Medicine, Suranaree University of Technology) ;
  • Matrakool, Likit (Department of Surgery, Institute of Medicine, Suranaree University of Technology) ;
  • Panpimanmas, Sukij (Department of Surgery, Institute of Medicine, Suranaree University of Technology)
  • Published : 2015.07.13


Background: Helicobacter pylori plays an important role in gastric cancer and typical eradication regimens are no longer effective in many countries, including Thailand. The aim of our study was to compare the effect of Lactobacillus delbrueckii and Streptococcus thermophillus on tailored triple therapy for Helicobacter pylori eradication. Materials and Methods: This prospective single-center study was conducted in Thailand. Helicobacter pylori associated gastritis patients were randomized to 2 groups: group 1 (n=100) was tailored triple therapy with placebo (esomeprazole 20 mg bid, clarithromycin 500 mg bid or metronidazole 400 mg tid if clarithromycin resistance and amoxicillin 1000 mg bid), and group 2 was tailored triple therapy plus pretreatment with probiotic containing yogurt. Successful eradication was defined as both negative histology and negative rapid urease test at four weeks after treatment. Results: A total of 200 infected patients were enrolled. PP analysis involved 194 patients: 96 in the tailored triple therapy with placebo group (group 1) and 98 the in tailored triple therapy plus pretreatment with probiotic containing yogurt group (group 2). Successful eradication was observed in 170 (87.6%) patients; by PP analysis, the eradication rate was significantly higher in group 2 (P = 0.04, 95%CI; 0.02-0.13) than in group 1. ITT analysis also showed that the value was significantly higher in the tailored triple threapy plus pretreatment with probiotic containing yogurt group (group 2) (89/100; 89%) than in the tailored triple therapy with placebo group (group 1) (P= 0.01, 95%CI; 0.04-0.15). In terms of adverse events, there was no significant difference between the two groups. Conclusions: Pretreatment with probiotic containing yogurt can improve Helicobacter pylori eradication rates with tailored triple therapy. Adding probiotics does not reduce adverse effects of the medication.


Pretreatment with probiotics;Helicobacter pylori;tailored triple therapy;gastric cancer


Supported by : Suranaree University of Technology


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