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Multi-Target Cytotoxic Actions of Flavonoids in Blood Cancer Cells

  • Sak, Katrin (Department of Hematology and Oncology, University of Tartu) ;
  • Everaus, Hele (Department of Hematology and Oncology, University of Tartu)
  • Published : 2015.07.13

Abstract

To date, cytotoxic effects of flavonoids in various cancer cells are well accepted. However, the intracellular signaling cascades triggered by these natural compounds remain largely unknown and elusive. In this mini-review, the multiplicity of molecular targets of flavonoids in blood cancer cells is discussed by demonstrating the involvement of various signaling pathways in induction of apoptotic responses. Although these data reveal a great potential of flavonoids for the development of novel agents against different types of hematological malignancies, the pleiotropic nature of these compounds in modulation of cellular processes and their interactions certainly need unraveling and further investigation.

Keywords

Natural flavonoids;blood cancer cells;cytotoxic action;multi-targeted signaling;reactive oxygen species

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