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Effects of multiple herb formula SEC-22 supplementation on dietary intake, picky eating behaviors, and growth indices in thin preschool children

  • Kim, Kijoon (Department of Food and Nutrition, Seoul National University) ;
  • Lee, Joonsuk (BOM Research Institute, Seoul National University) ;
  • Paik, Hee Young (Department of Food and Nutrition, Seoul National University) ;
  • Yoon, Jihyun (Department of Food and Nutrition, Seoul National University) ;
  • Ryu, Bongha (3rd department of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Shim, Jae Eun (Department of Food and Nutrition, Daejeon University)
  • Received : 2014.10.31
  • Accepted : 2015.04.05
  • Published : 2015.08.01

Abstract

BACKGROUND/OBJECTIVES: Thin children may have insufficient intake of energy and nutrients, resulting in reduced immune function and growth. This study aimed to identify the effects of multiple herb formula SEC-22 supplementation on growth, dietary changes, and picky eating behaviors in thin children. SUBJECTS/METHODS: A double-blind, randomized clinical trial was conducted on 79 children aged 2-5 years with poor appetites, BMI percentile < 25, and without any illness. Subjects were given either SEC-22 (n = 35) or placebo (n = 44) for 2 months and followed for an additional 2 months. Three-day dietary records, questionnaires on picky eating behaviors, and anthropometric measures were collected. RESULTS: Energy, carbohydrate intake, and feeding difficulty improved in both groups during the intervention period. However, changes were maintained only in the SEC-22 group after 2 months of follow-up post-supplementation. 'Frequency of trying to feed' was improved in the SEC-22 group compared to the placebo group after the first month of follow-up (P < 0.05). Intakes of potassium and thiamine were improved in the SEC-22 group compared to the placebo group after the first month of intervention (P < 0.05). 'Frequency of food reward', eating amount, and intakes of carbohydrate, potassium, and vitamin C showed significant improvement compared to the placebo group after the second month of follow-up (P < 0.05). CONCLUSIONS: These results suggest that SEC-22 supplementation can improve parental feeding difficulty resulting from insufficient eating amount or picky eating as well as increase nutrient intake in thin children. Although these improvements were observable at least 2 months after supplementation, effects beyond this time frame need to be confirmed.

References

  1. Lee YS, Lim HS, Ahn HS, Chang NS. Nutrition Throughout the Life Cycle. Paju: Kyomunsa; 2006. p.199-207.
  2. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson CL. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11 2002:1-190.
  3. Ali D, Saha KK, Nguyen PH, Diressie MT, Ruel MT, Menon P, Rawat R. Household food insecurity is associated with higher child undernutrition in Bangladesh, Ethiopia, and Vietnam, but the effect is not mediated by child dietary diversity. J Nutr 2013;143:2015-21. https://doi.org/10.3945/jn.113.175182
  4. Hovhannisyan L, Demirchyan A, Petrosyan V. Estimated prevalence and predictors of undernutrition among children aged 5-17 months in Yerevan, Armenia. Public Health Nutr 2014;17:1046-53. https://doi.org/10.1017/S1368980013001171
  5. Singh A, Singh A, Ram F. Household food insecurity and nutritional status of children and women in Nepal. Food Nutr Bull 2014;35:3-11. https://doi.org/10.1177/156482651403500101
  6. Sandjaja, Poh BK, Rojroonwasinkul N, Le Nyugen BK, Budiman B, Ng LO, Soonthorndhada K, Xuyen HT, Deurenberg P, Parikh P; SEANUTS Study Group. Relationship between anthropometric indicators and cognitive performance in Southeast Asian schoolaged children. Br J Nutr 2013;110 Suppl 3:S57-64. https://doi.org/10.1017/S0007114513002079
  7. Bhagowalia P, Chen SE, Masters WA. Effects and determinants of mild underweight among preschool children across countries and over time. Econ Hum Biol 2011;9:66-77. https://doi.org/10.1016/j.ehb.2010.05.002
  8. Fawzi WW, Herrera MG, Spiegelman DL, el Amin A, Nestel P, Mohamed KA. A prospective study of malnutrition in relation to child mortality in the Sudan. Am J Clin Nutr 1997;65:1062-9. https://doi.org/10.1093/ajcn/65.4.1062
  9. Jilcott SB, Ickes SB, Ammerman AS, Myhre JA. Iterative design, implementation and evaluation of a supplemental feeding program for underweight children ages 6-59 months in Western Uganda. Matern Child Health J 2010;14:299-306. https://doi.org/10.1007/s10995-009-0456-3
  10. Maleta K, Kuittinen J, Duggan MB, Briend A, Manary M, Wales J, Kulmala T, Ashorn P. Supplementary feeding of underweight, stunted Malawian children with a ready-to-use food. J Pediatr Gastroenterol Nutr 2004;38:152-8. https://doi.org/10.1097/00005176-200402000-00010
  11. Thakwalakwa C, Ashorn P, Phuka J, Cheung YB, Briend A, Puumalainen T, Maleta K. A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6- to 18-month-old moderately underweight children in rural Malawi. J Nutr 2010;140:2008-13. https://doi.org/10.3945/jn.110.122499
  12. Bekem O, Buyukgebiz B, Aydin A, Ozturk Y, Tasci C, Arslan N, Durak H. Prokinetic agents in childen with poor appetite. Acta Gastroenterol Belg 2005;68:416-8.
  13. Talley NJ, Quan C, Jones MP, Horowitz M. Association of upper and lower gastrointestinal tract symptoms with body mass index in an Australian cohort. Neurogastroenterol Motil 2004;16:413-9. https://doi.org/10.1111/j.1365-2982.2004.00530.x
  14. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115:1346-52. https://doi.org/10.1016/S0016-5085(98)70012-5
  15. Ekstein S, Laniado D, Glick B. Does picky eating affect weight-forlength measurements in young children? Clin Pediatr (Phila) 2010; 49:217-20. https://doi.org/10.1177/0009922809337331
  16. Shim JE, Yoon JH, Kim K, Paik HY. Association between picky eating behaviors and growth in preschool children. J Nutr Health 2013;46: 418-26. https://doi.org/10.4163/jnh.2013.46.5.418
  17. World Health Organization (CH); Food and Agriculture Organization (US). WHO Technical Report Series 916. Diet, Nutrition and the Prevention of Chronic Diseases. Report of a Joint WHO/FAO Expert Consultation. Geneva: World Health Organization; 2003.
  18. Heo J. DonguiBogam. Seoul: Namsandang; 1994. p.435.
  19. Department of Internal Medicine. New Internal Medicine-Bi's System. Iksan: Wonkwang University Press; 1996. p.36-37.
  20. Morley JE. Anorexia of aging: physiologic and pathologic. Am J Clin Nutr 1997;66:760-73. https://doi.org/10.1093/ajcn/66.4.760
  21. Carruth BR, Skinner J, Houck K, Moran J 3rd, Coletta F, Ott D. The phenomenon of "picky eater": a behavioral marker in eating patterns of toddlers. J Am Coll Nutr 1998;17:180-6. https://doi.org/10.1080/07315724.1998.10718744
  22. Le Nguyen BK, Le Thi H, Nguyen Do VA, Tran Thuy N, Nguyen Huu C, Thanh Do T, Deurenberg P, Khouw I. Double burden of undernutrition and overnutrition in Vietnam in 2011: results of the SEANUTS study in 0.5-11-year-old children. Br J Nutr 2013;110 Suppl 3:S45-56. https://doi.org/10.1017/S0007114513002080
  23. Poh BK, Ng BK, Siti Haslinda MD, Nik Shanita S, Wong JE, Budin SB, Ruzita AT, Ng LO, Khouw I, Norimah AK. Nutritional status and dietary intakes of children aged 6 months to 12 years: findings of the Nutrition Survey of Malaysian Children (SEANUTS Malaysia). Br J Nutr 2013;110 Suppl 3:S21-35. https://doi.org/10.1017/S0007114513002092
  24. Kim KJ, Lee JS, Yoon JH, Ryu BH, Paik HY. The weight gain effects of Sungjangjeungbo-tang (Chengzhangzengbu-tang) on thin Korean preschool children. J Korean Orient Intern Med 2012;33:180-7.
  25. Wu J, Peng W, Qin R, Zhou H. Crataegus pinnatifida: chemical constituents, pharmacology, and potential applications. Molecules 2014;19:1685-712. https://doi.org/10.3390/molecules19021685
  26. Wen XP, Deng S, Lin Y, Diao YP, Shan HS, Zhang HL. Effects of folium crataegi water extract on the contractility of isolated gastric and intestinal muscle strips in rats. China Pharm 2010;21:978-80.
  27. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton (FL): CRC Press; 1998. p.120.
  28. Jeong SI, Kim YS, Lee MY, Kang JK, Lee S, Choi BK, Jung KY. Regulation of contractile activity by magnolol in the rat isolated gastrointestinal tracts. Pharmacol Res 2009;59:183-8. https://doi.org/10.1016/j.phrs.2008.11.008
  29. Choi HK, Roh HS, Jeong JY, Ha HY. Acute oral toxicity of Atractylodes macrocepala KOIDZ. Korean J Plant Resour 2014;27:11-21. https://doi.org/10.7732/kjpr.2014.27.1.011
  30. Kim HC. Pharmacology of Herbal Medicines. Paju: Jipmoondang; 2008. p.267.
  31. Kim HC. Pharmacology of Herbal Medicines. Paju: Jipmoondang; 2008. p.286
  32. Lee YS, Kang MH, Cho SY, Jeong CS. Effects of constituents of Amomum xanthioides on gastritis in rats and on growth of gastric cancer cells. Arch Pharm Res 2007;30:436-43. https://doi.org/10.1007/BF02980217
  33. Hua Y. Chinese Medicine Herbalogy. Beijing: People's Medical Publishing House Co. Ltd.; 1991. p.321-322.
  34. Kim HC. Pharmacology of Herbal Medicines. Paju: Jipmoondang; 2008. p.216.
  35. Hu ML, Rayner CK, Wu KL, Chuah SK, Tai WC, Chou YP, Chiu YC, Chiu KW, Hu TH. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol 2011;17:105-10. https://doi.org/10.3748/wjg.v17.i1.105
  36. Lohsiriwat S, Rukkiat M, Chaikomin R, Leelakusolvong S. Effect of ginger on lower esophageal sphincter pressure. J Med Assoc Thai 2010;93:366-72.
  37. Shariatpanahi ZV, Taleban FA, Mokhtari M, Shahbazi S. Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit. J Crit Care 2010;25:647-50. https://doi.org/10.1016/j.jcrc.2009.12.008
  38. Wood GB. A Treatise on Therapeutics, and Pharmacology or Materia Medica. 2nd ed. Philadelphia (PA): J. B. Lippincott & Co.; 1860. p.355.
  39. Bradley P. British Herbal Compendium. Volume 1. A Handbook of Scientific Information on Widely Used Plant Drugs. Bournemouth: British Herbal Medicine Association; 1992. p.112-4.
  40. Wu H, Ye D, Bai Y, Zhao Y. Effect of dry ginger and roasted ginger on experimental gastric ulcers in rats. Zhongguo Zhong Yao Za Zhi 1990;15:278-80, 317-8.
  41. Kim HC. Pharmacology of Herbal Medicines. Paju: Jipmoondang; 2008. p.84.
  42. Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton (FL): CRC Press; 1998. p.155-6.
  43. Shim JE, Kim J, Mathai RA; STRONG Kids Research Team. Associations of infant feeding practices and picky eating behaviors of preschool children. J Am Diet Assoc 2011;111:1363-8. https://doi.org/10.1016/j.jada.2011.06.410