The interaction of Apolipoprotein A5 gene promoter region T-1131C polymorphism (rs12286037) and lifestyle modification on plasma triglyceride levels in Japanese

  • Yamasaki, Masayuki (Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University) ;
  • Mutombo, Paulin Beya wa Bitadi (Department of Nutrition, School of Public Health, Faculty of Medicine, University of Kinshasa) ;
  • Iwamoto, Mamiko (Department of Environmental and Preventive Medicine, Faculty of Medicine, Shimane University) ;
  • Nogi, Akiko (Department of Human Nutrition, Faculty of Nursing and Human Nutrition, Yamaguchi Prefectural University) ;
  • Hashimoto, Michio (Department of Environmental Physiology, Faculty of Medicine, Shimane University) ;
  • Nabika, Toru (Department of Functional Pathology, Faculty of Medicine, Shimane University) ;
  • Shiwaku, Kuninori (Shimane University)
  • Received : 2014.09.15
  • Accepted : 2014.12.14
  • Published : 2015.08.01


BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program. SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: $57{\pm}8years$) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification. RESULTS: Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, $126{\pm}68mg/dl$; TC, $134{\pm}74mg/dl$; and CC, $172{\pm}101mg/dl$. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: $-21.9{\pm}61.0mg/dl$, $-20.9{\pm}51.0mg/dl$, and $-42.6{\pm}78.5mg/dl$, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels. CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.


Supported by : Japanese Ministry of Education, Culture, Sports, Science and Technology


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