Effects of Cosmetics and Their Preservatives on the Growth and Composition of Human Skin Microbiota

피부 미생물총의 생장과 구성에 대한 화장품과 그 방부제의 영향

  • Jeong, Jin-Ju (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University) ;
  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
  • 정진주 (경희대학교 나노의약생명과학과) ;
  • 김동현 (경희대학교 나노의약생명과학과)
  • Received : 2015.03.06
  • Accepted : 2015.06.16
  • Published : 2015.06.30


We investigated the growth-inhibitory activities of cosmetics and their preservatives against pathogens and resident skin bacteria. Of the tested cosmetics, preservatives such as parabens, 1,2-hexanediol, phenoxyethanol-contained toner, emulsion, cream and baby cream exhibited potent antibacterial effects against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Parabens, 1,2-hexanediol and phenoxyethanol inhibited the growth of pathogens, as well as skin-resident bacteria such as Staphilococcus epidermidis, Shigella flexneri, Enterobacter aerogenes and so on. The application of a basic cream containing phenoxyethanol to human skin was shown to disturb the skin microbiota: at the phylum level, Proteobacteria increased and at species level, 4P004125_s increased and Propionibacterium humerusii decreased. Based on these findings, parabens, 1,2-hexanediol and phenoxyethanol have antimicrobial activity and cosmetics containing phenoxyethanol may disturb skin microbiota.


cosmetic;preservative;skin microbiota;growth inhibition


Supported by : Ministry of Food and Drug Safety


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