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Whitening Effect of Androsace umbellata Extract

봄맞이 추출물의 미백 효능 연구

  • Kim, Bo Yun (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Park, Sung Ha (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Park, Byoung Jun (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Kim, Jin Jun (Bio Materials R&D center, Kolmar Korea, CBTP, Future Convergent Tech Center)
  • 김보윤 (한국콜마(주) 소재연구소) ;
  • 박성하 (한국콜마(주) 소재연구소) ;
  • 박병준 (한국콜마(주) 소재연구소) ;
  • 김진준 (한국콜마(주) 소재연구소)
  • Received : 2014.11.05
  • Accepted : 2015.03.19
  • Published : 2015.03.31

Abstract

The purpose of this study is to identify the whitening effect of Androsace umbellata extract. To discover the anti-pigmentation effective, we investigated Androsace umbellata extract on tyrosinase and melanogenesis inhibition. As results, it reduced tyrosinase activity and melanin contents in B16F1 melanoma cells in a dose-dependent manner with decreased to about 32% at a concentration of $25{\mu}g/mL$. To reveal how it works in inner-cellular level, we performed Western blot method. We found out that it also inhibited the protein expression in tyrosinase, tyrosinase related protein 1 (TRP-1), and microphthalmia associated transcription factor (MITF) in melanocytes. Therefore, we successfully identified the whitening effect of Androsace umbellata extract, and this finding suggested that Androsace umbellata extract is a considerable potent cosmetics ingredient for whitening. Based on this, we anticipated further researches about Androsace umbellata extract for gene levels and additional mechanisms to develop not only for functional cosmetics but for medicines or healthcare food.

Keywords

Androsace umbellata;whitening;tyrosinase;melanin

Acknowledgement

Supported by : 지식경제부

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