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Life of T Follicular Helper Cells

  • Suh, Woong-Kyung (Clinical Research Institute of Montreal (IRCM), University of Montreal, and McGill University)
  • Received : 2014.12.01
  • Accepted : 2014.12.04
  • Published : 2015.03.31

Abstract

Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.

Keywords

antibody;costimulation;germinal center;T follicular helper

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  2. Vaccine Induction of Lymph Node–Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques vol.196, pp.4, 2016, https://doi.org/10.4049/jimmunol.1502137
  3. Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases vol.22, pp.5, 2016, https://doi.org/10.1097/MIB.0000000000000714
  4. The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza vol.7, 2016, https://doi.org/10.3389/fimmu.2016.00010
  5. Adaptive immunity in the liver vol.13, pp.3, 2016, https://doi.org/10.1038/cmi.2016.4
  6. Follicular helper T cell in immunity and autoimmunity vol.49, pp.5, 2016, https://doi.org/10.1590/1414-431X20165209
  7. Activated T follicular helper-like cells are released into blood after oral vaccination and correlate with vaccine specific mucosal B-cell memory vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-20740-3
  8. T cells in IgA nephropathy: role in pathogenesis, clinical significance and potential therapeutic target pp.1437-7799, 2018, https://doi.org/10.1007/s10157-018-1665-0
  9. T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response pp.2164-554X, 2018, https://doi.org/10.1080/21645515.2018.1495303