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Survival Effect of Supportive Care Services for Turkish Patients with Metastatic Gastric Cancer

  • Namal, Esat (Department of Medical Oncology, Florence Nightingale Hospital) ;
  • Ercetin, Candas (Department of General Surgery, Bagcilar Training and Research Hospital) ;
  • Tokocin, Merve (Department of General Surgery, Bagcilar Training and Research Hospital) ;
  • Akcali, Zafer (Department of Medical Oncology, Ufuk University, Dr. Ridvan Ege Hospital) ;
  • Yigitbas, Hakan (Department of General Surgery, Bagcilar Training and Research Hospital) ;
  • Yavuz, Erkan (Department of General Surgery, Bagcilar Training and Research Hospital) ;
  • Celebi, Fatih (Department of General Surgery, Bagcilar Training and Research Hospital) ;
  • Totoz, Tolga (Department of Anesthesiology, Bagcilar Training and Research Hospital) ;
  • Pamukcu, Ozgul (Department of Internal Medicine, Sisli Etfal Training and Research Hospital) ;
  • Saglam, Emel (Department of Internal Medicine, Bagcilar Training and Research Hospital)
  • Published : 2015.03.04

Abstract

Background: Gastric cancer is the second most common cause of cancer- related deaths worldwide and ranks $11^{th}$ or $14^{th}$ among all deaths. Patients with advanced disease require supportive care along with the medical and/or surgical treatment. Aim: To assess the need for palliative care for patients with advanced tumours along with standard clinical therapy. Materials and Methods: Eighty-four patients with metastatic (stage 4) gastric cancer, including both patients who had received surgical treatment or not, were followed up in Bagcilar Training and Research Hospital, Division of Medical Oncology between 2011 and 2014. They were categorised as supportive care (-) (Group 1, n=37) and (+) groups (Group 2, n=47) and evaluated retrospectively. Results: Demographic characteristics of the patients were as follows: mean age, Group 1, $65.2{\pm}10.5$ years, Group $2,63.7{\pm}11.3$ years; male/female ratio, Group 1, 21/16, Group 2, 28/19; distribution of Eastern Cooperative Oncology Group (ECOG) performance scores of 0 and 1, Group 1, ECOG 0 (n=9) and 1 (n=14), Group 2, ECOG 0 (34) and 1 (n=13) (p<0.0001); patients receiving second-line, Group 1 (n=7) and Group 2 (n=22) (p<0.008) or third - line chemotherapy,Group 2 (n=6) (p<0.02); mortality rates, Group 1, (n=28; 75.6%) and Group 2 (n=30; 63.8%); progression-free survival (PFS) rates, Group 1, $17.4{\pm}6$ weeks, Group 2, $28.3{\pm}16.2$ weeks; statistically significant overall survival rates, Group 1, $20.8{\pm}8.2$ weeks and Group 2, $28.3{\pm}162$ weeks (p<0.01). Conclusions: The supportive care team (medical oncologist, general surgeon, internal medicine specialist, algologist, psychiatrist and radiologist) can play a role in the treatment of metastatic gastric tumours, with improvements shown in terms of the performance status of cases, eligibility of patients to be on chemotherapy programmes for longer duration and overall survival rates in Turkey.

Keywords

Metastatic gastric cancer;supportive care team;chemotherapy;Turkey

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