Asian Pacific Journal of Cancer Prevention

Asian Pacific Organization for Cancer Prevention (아시아태평양암예방학회)
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Hypermethylation of TET1 Promoter Is a New Diagnosic Marker for Breast Cancer Metastasis

  • Sang, Yi (Department of Center Laboratory, the Third Affiliated Hospital, Nanchang University) ;
  • Cheng, Chun (Department of Center Laboratory, the Third Affiliated Hospital, Nanchang University) ;
  • Tang, Xiao-Feng (Department of Center Laboratory, the Third Affiliated Hospital, Nanchang University) ;
  • Zhang, Mei-Fang (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Lv, Xiao-Bin (Department of Center Laboratory, the Third Affiliated Hospital, Nanchang University)
  • Published : 2015.03.04

Abstract

Breast cancer metastasis is a major cause of cancer-related death in women. However, markers for diagnosis of breast cancer metastasis are rare. Here, we reported that TET1, a tumor suppressor gene, was downregulated and hypermethylated in highly metastatic breast cancer cell lines. Moreover, silencing of TET1 in breast cancer cells increased the migration and spreading of breast cancer cells. In breast cancer clinical samples, TET1 expression was reduced in LN metastases compared with primary tissues. Besides, the methylation level of the TET1 promoter was increased significantly in LN metastases. Taken together, these findings indicate that promoter hypermethylation may contribute to the downregulation of TET1 and could be used as a promising marker for diagnosis in patients with breast cancer metastasis.

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