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Quantitative Assessment of the Diagnostic Role of CDH13 Promoter Methylation in Lung Cancer

  • Zhong, Yun-Hua (Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus) ;
  • Peng, Hao (Thoracic Surgery, the First People's Hospital of Yunnan Province, Panlong Campus) ;
  • Cheng, Hong-Zhong (Thoracic Surgery, the First People's Hospital of Yunnan Province, Panlong Campus) ;
  • Wang, Ping (Thoracic Surgery, the First People's Hospital of Yunnan Province, Panlong Campus)
  • Published : 2015.03.04

Abstract

In order to explore the association between cadherin 13 (CDH13) gene promoter methylation and lung carcinoma (LC) risk, we carried out a meta-analysis with searching of PubMed, Web of Science. Ultimately, 17 articles were identified and analysised by STATA 12.0 software. Overall, we found a significant relationship between CDH13 promoter methylation and LC risk (odds ratio=6.98, 95% confidence interval: 4.21-11.56, p<0.001). Subgroup analyses further revealed that LC risk was increased for individuals carrying the methylated CDH13 compared with those with unmethylated CDH13. Hence, our study identified a strong association between CDH13 gene promoter methylation and LC and highlighted a promising potential for CDH13 methylation in LC risk prediction.

Keywords

CDH13;lung carcinoma;methylation

Acknowledgement

Supported by : Specialized Research Fund

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