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TRAIL and Bortezomib: Killing Cancer with Two Stones

  • Qureshi, Muhammad Zahid (Department of Chemistry, GCU Lahore) ;
  • Romero, Mirna Azalea (Laboratorio de Farmacologia, Unidad Academica de Medicina, Universidad Autonoma de Guerrero) ;
  • Attar, Rukset (Department of Obstetrics and Gynecology, Yeditepe University Faculty of Medicine) ;
  • Javed, Zeeshan (Chughtais Lahore Lab, Rashid Latif Medical College) ;
  • Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College)
  • Published : 2015.03.09

Abstract

Cancer genomics and proteomics have undergone considerable broadening in the past decades and increasingly it is being realized that solid/liquid phase microarrays and high-throughput resequencing have provided platforms to improve our existing knowledge of determinants of cancer development, progression and survival. Loss of apoptosis is a widely and deeply studied process and different approaches are being used to restore apoptosis in resistant cancer phenotype. Modulating the balance between pro-apoptotic and anti-apoptotic proteins is essential to induce apoptosis. It is becoming more understood that pharmacological inhibition of the proteasome might prove to be an effective option in improving TRAIL induced apoptosis in cancer cells. Keeping in view rapidly accumulating evidence of carcinogenesis, metastasis, resistance against wide ranging therapeutics and loss of apoptosis, better knowledge regarding tumor suppressors, oncogenes, pro-apoptotic and anti-apotptic proteins will be helpful in translating the findings from benchtop to bedside.

Keywords

Apoptosis;TRAIL;signaling;cancer;bortezomib

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