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Increased UGT1A3 and UGT1A7 Expression is Associated with Pancreatic Cancer

  • Yilmaz, Latif (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Borazan, Ersin (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Aytekin, Turkan (Department of Biology, Faculty of Arts and Sciences, Gaziantep University) ;
  • Baskonus, Ilyas (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Aytekin, Alper (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Oztuzcu, Serdar (Department of Medical Biology, Faculty of Medicine, Gaziantep University) ;
  • Bozdag, Zehra (Department of Pathology, Faculty of Medicine, Gaziantep University) ;
  • Balik, Ahmet (Department of General Surgery, Faculty of Medicine, University of Gaziantep)
  • Published : 2015.03.09

Abstract

UGT1A play important roles in the glucuronidation of a variety of endogenous and exogenous compounds. UGT1A isoforms are expressed tissue specifically. The aim of this study was to examine the relationship between UGT1A3 and UGT1A7 mRNA expression and pancreatic cancer. Paired healthy and tumor tissue samples of 43 patients with pancreatic cancer were included in this study. UGT1A3 and UGT1A7 mRNA expressions were analyzed by real time-PCR. In the result of study, UGT1A3 and UGT1A7 mRNA expressions were significantly higher in tumor tissue than normal tissue of pancreatic cancer patients (p<0.05). In addition, high mRNA expression of UGT1A3 and UGT1A7 was significantly associated with larger tumor size (p<0.05). The data suggested that UGT1A3 and UGT1A7 may play roles in the progression of pancreatic cancer. Consequently, UGT1A3 and UGT1A7 are potential prognostic indicators.

Keywords

UGT1A3;UGT1A7;expression;pancreatic cancer

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