DOI QR코드

DOI QR Code

Male Breast Cancer: a 24 Year Experience of a Tertiary Care Hospital in Pakistan

  • Jamy, Omer (Department of Internal Medicine, The University of Tennessee Health Science Center) ;
  • Rafiq, Ammar (Department of Surgery Aga Khan University Hospital) ;
  • Laghari, Altaf (Department of Surgery Aga Khan University Hospital) ;
  • Chawla, Tabish (Department of Surgery Aga Khan University Hospital)
  • Published : 2015.03.09

Abstract

Background: Male breast cancer accounts for less than 1% of all cancers found in men. It usually presents at a later age and stage as compared to female breast cancer. Treatment strategies are extrapolated from the management of female breast cancer. Our study here looked at 18 patients diagnosed with and treated for male breast cancer at The Aga Khan University Hospital in Pakistan. We compared our findings with the existing data from Asian and Western countries. Materials and Methods: A retrospective study was conducted looking at patients with male breast cancer between January 1986 and December 2009. Patient and disease characteristics were analyzed and 5 year overall survival was calculated using Microsoft Excel and SPSS. Results: The average age at diagnosis was 52 years (38-67 years). Twelve (66.7%) patients had axillary lymphadenopathy. Stage II disease was the most common stage at presentation (9 patients, 50%). Infiltrating ductal carcinoma was seen in 16 patients (88.8%). Seven lesions were positive for both estrogen and progesterone receptors. Sixteen patients had surgery in the form of either modified radical mastectomy or radical mastectomy. Radiation was used in 7 patients in an adjuvant setting. The five year overall survival for stage I, II, III and IV disease was 100% vs 78% vs 50% vs 0%( p<0.05). Five year overall survival was 61%. None of the other prognostic factors were statistically significant. Median follow up was 15 months (3-202 months). Conclusions: Male breast cancer may be on a slow rise but is still an uncommon disease. Tumor stage and lymph node status are important prognostic markers. Public awareness and screening may help in detecting the disease at an earlier stage. Prospective trials are needed to improve the management of this disease.

Keywords

Male breast cancer;female breast cancer;overall survival;prognostic factors;Pakistan

References

  1. Anderson WF, Jatoi I, Tse J, et al (2010). Male breast cancer: a population-based comparison with female breast cancer. J Clin Oncol, 28, 232-9. https://doi.org/10.1200/JCO.2009.23.8162
  2. Brinton LA, Richesson DA, Gierach GL, et al (2008). Prospective evaluation of risk factors for male breast cancer. J Natl Cancer Inst, 100, 1477-81. https://doi.org/10.1093/jnci/djn329
  3. Chikaraddi SB, Krishnappa R, Deshmane V (2012). Male breast cancer in Indian patients: is it the same? Indian J Cancer, 49, 272-6. https://doi.org/10.4103/0019-509X.104484
  4. Giordano SH, Cohen DS, Buzdar AU, et al (2004). Breast carcinoma in men: a population-based study. Cancer, 101, 51-7. https://doi.org/10.1002/cncr.20312
  5. Jamal S, Mamoon N, Mushtaq S, et al (2006). Carcinoma of the male breast: a study of 141 cases from northern Pakistan. Asian Pac J Cancer Prev, 7, 119-21.
  6. Jamal S, Mushtaq H, Mubarik A, et al (2009). Estrogen receptor, progesterone receptor, HER2/neu, P53 and Ki-67 status of male breast carcinomas in Pakistan. Asian Pac J Cancer Prev, 10, 1067-70.
  7. Kassim-Lakha S, Bennett J (2013). Philanthropic funding for health in Pakistan. Lancet, 381, 2236-7. https://doi.org/10.1016/S0140-6736(13)60678-9
  8. Kaushik M, Oliveira-Cunha M, Shokuhi S (2014). Male breast cancer: a single centre experience and current evidence. Breast J, 20, 674-5. https://doi.org/10.1111/tbj.12346
  9. Miao H, Verkooijen HM, Chia KS, et al (2011). Incidence and outcome of male breast cancer: an international populationbased study. J Clin Oncol, 29, 4381-6. https://doi.org/10.1200/JCO.2011.36.8902
  10. Nahleh ZA, Srikantiah R, Safa M, et al (2007). Male breast cancer in the veterans affairs population: a comparative analysis. Cancer, 109, 1471-7. https://doi.org/10.1002/cncr.22589
  11. Sedighi A, Hamed EA, Mohammadian K, et al (2013). Clinicopathologic characteristics of male breast cancer: a report of 21 cases in radiotherapy center of Hamedan, Iran. Asian Pac J Cancer Prev, 14, 7381-3. https://doi.org/10.7314/APJCP.2013.14.12.7381
  12. Selcukbiricik F, Tural D, Aydogan F, et al (2013). Male breast cancer: 37-year data study at a single experience center in Turkey. J Breast Cancer, 16, 60-5. https://doi.org/10.4048/jbc.2013.16.1.60
  13. Shah S, Bhattacharyya S, Gupta A, et al (2012). Male breast cancer: a clinicopathologic study of 42 patients in eastern India. Indian J Surg Oncol, 3, 245-9. https://doi.org/10.1007/s13193-012-0163-1
  14. Sipetic-Grujicic SB, Murtezani ZH, Neskovic-Konstatinovic ZB, et al (2014). Multivariate analysis of prognostic factors in male breast cancer in Serbia. Asian Pac J Cancer Prev, 15, 3233-8. https://doi.org/10.7314/APJCP.2014.15.7.3233
  15. Soliman AA, Denewer AT, El-Sadda W, et al (2014). A retrospective analysis of survival and prognostic factors of male breast cancer from a single center. BMC Cancer, 14, 227. https://doi.org/10.1186/1471-2407-14-227
  16. Tasneem S, Khan MM, Khawaja MY (2011). Demographic pattern of male breast cancer: an institutional based study. J Ayub Med Coll Abbottabad, 23, 3-4.
  17. Zhou R, Yu L, Zhou S, et al (2014). Male breast carcinoma: a clinicopathological and immunohistochemical characterization study. Int J Clin Exp Pathol, 7, 6852-61.
  18. Zygogianni AG, Kyrgias G, Gennatas C, et al (2012). Male breast carcinoma: epidemiology, risk factors and current therapeutic approaches. Asian Pac J Cancer Prev, 13, 15-9. https://doi.org/10.7314/APJCP.2012.13.1.015

Cited by

  1. The Epidemiology of Male Breast Cancer vol.18, pp.1, 2016, https://doi.org/10.1007/s11912-015-0487-4