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Exogenous Natural Glycoprotein Multiple Mechanisms of Anti-tumor Activity

  • Yuan, Hong-Liang (Harbin Commercial University Life Science and Environmental Science Research Center) ;
  • Liu, Xiao-Lei (College of Pharmacy, Harbin University of Commerce) ;
  • Dai, Qi-Chang (Harbin Commercial University Life Science and Environmental Science Research Center) ;
  • Song, Hui (Harbin Commercial University Life Science and Environmental Science Research Center)
  • Published : 2015.03.09

Abstract

Natural glycoproteins can induce apoptosis of tumor cells and exert anti-tumor activity by immunomodulatory functions, cytotoxic and anti-inflammation effects, and inhibition of endothelial growth factor. Given their prospects as novel agents, sources of natural antitumor glycoproteins have attracted attention and new research directions in glycoprotein biology are gradually shifting to the direction of cancer treatment and prevention of neoplastic disease. In this review, we summarize the latest findings with regard to the tumor suppressor signature of glycoproteins and underlying regulatory mechanisms.

Keywords

Glycoprotein;antitumor;immunomodulatory;cytotoxicity;antiinflammation;endothelial growth factor

Acknowledgement

Supported by : Commerce Natural Science Foundation

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