DOI QR코드

DOI QR Code

Effects of Taraxaci Herba on the Sex Hormon Changes and Lipid Metabolism in the Ovariectomized Rats

포공영이 난소적출 흰쥐의 성호르몬 변화 및 지질대사에 미치는 영향

  • Received : 2015.01.22
  • Accepted : 2015.02.07
  • Published : 2015.02.27

Abstract

Objectives: Taraxaci Herba (TH) have been used in oriental medicine for many centuries as a heat-clearing, detoxifying and stimulating milk secretion drug. Therefore, the purpose of this study was to investigate the effects of TH on the sex hormone changes and lipid metabolism in the experimental model. Methods: The experimental model of menopause was induced by bilateral ovariectomy in rats. We used TH extract with freeze-dried and $200{\pm}20g$ female Sprague-dawley rats for this Study. The level of serum total cholesterol, serum triglyceride, serum HDL-cholesterol, serum total estrogen, serum progesterone, serum follicle stimulating hormone (FSH), and body weight were measured. Results: The results of this study were obtained as follows; 1. Sample A and Sample B significantly decreased body weight and level of serum total cholesterol, and significantly increased level of serum total estrogen as compared with control group. 2. Sample A decreased level of serum triglyceride, and was increased level of HDL-cholesterol, serum progesterone, serum FSH as compared with control group. 3. Sample B significantly increased level of HDL-cholesterol, serum FSH as compared with control group. 4. Sample B decreased level of serum triglyceride, and was increased level of serum progesterone as compared with control group. Conclusions: These results suggest that TH could be applied effectively on the treatment of menopausal syndrome.

Keywords

Menopausal Syndrome;Taraxaci Herba;Sex Hormon Changes;Lipid Metabolism

References

  1. Anthony M, et al. Realtionship of fasting urinary calcium to circlulating estrogen and body weight in postmenopausal women. JCM&M. 1980;50(1):70-5.
  2. Lee BH. Physiology. Seoul:Sinkwang publisher. 1976:207-11.
  3. Yuánhuīmèng. Old age menopause symptoms. Shanghai:Shanghai Science and Technology Press. 1984:208-15.
  4. Kim BC, Kim DH, Heo M. A Study of Symptomatology, Lipid Changes and Hormonal Changes in the Menopausal Women. Obstetrics & Gynecology Science. 1988;31(6):784-94.
  5. Seo DY, Park HM, Bae DH. The Effect of Bilateral Oophorectomy and Estrogen Replacement Therapy on Dynamic Changes of Serum Pituitrary Gonadotropin and Estrogen Levels in Premenopausal Women. In-house test data. Daiichi Pure Chemical Methods, 6th ed.
  6. Kim SY, Lee IS. The Effect of the Yukmichiwhang-won and the Puickchiwhang -whan on Sex Hormones Changes and Lipid Metabolism in the Ovariectomized Rats. Obstetrics & Gynecology Science. 1998;11(1):175-91.
  7. Obstetrics & Gynecology Science. Gynecology. Seoul:Kalbin publisher. 1991:64-8, 309-36, 378-80.
  8. Kim MS, et al. Combined Estrogen-Progesterone(Divina) Treatment in Postmenopausal Women with Special Reference to Serum Lipoprotein Patterns. Endocrinology and Metabolism. 1992; 7(3):267-72.
  9. Lee YJ, M Hong. Cardiovascular Effect of Hormone Replacement Therapy in Postmenopausal Women. Obstetrics & Gynecology Science. 1996;39(10) :494-4755.
  10. Poehlman ET. Menopause, energy expenditure, and body composition. Acta Obstet Gynecol Scand. 2002;81(7):603-11. https://doi.org/10.1034/j.1600-0412.2002.810705.x
  11. Samat A, Rahim A, Barnett A. Pharmacotherapy for obesity in menopausal women. Menopause Int. 2008;14(2):57-62.
  12. Tchernof A, et al. Menopause, central body fatness, and insulin resistance: effects of hormone-replacement therapy. Coron Artery Dis. 1998;9(8):503-11. https://doi.org/10.1097/00019501-199809080-00006
  13. Kim SM, et al. A Clinical study on the Effect of Daejo-hwan on Climecteric Syndrome. The Journal of oriental obstetrics & Gynecology. 2006;19(4) :244-55.
  14. Jin JP. Hwangjaenaekyoungdoksong. Seoul:Bupin publisher. 2009:21.
  15. Guichen. TCM clinical gynecology. Beijing:People's Medical Publishing House. 1994:232-42.
  16. Hóng jiā tiě. Zhōng xīyī línchuáng fù kēxué. Beijing:Zhōngyī zhōngyào chūbǎn shè. 1996;416-8.
  17. Kim KS, DY Yoo. Literary Study on the Climecteric Syndrome. Taejon University. 2004;3(1):127.
  18. Dike N, et al. Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factoe-Ⅰ and insulin-like growth factor binding protein-3. Bone and Mineral. 1994; 25:135-67. https://doi.org/10.1016/S0169-6009(08)80255-3
  19. Aitken JM, Armstrong E, Anderson J. Osteoporosis after oophorectomy in the mature female rat and the effects of estrogen and/or progestogen replacement therapy in its prevention, J. Endocr. 1972;55:79-87. https://doi.org/10.1677/joe.0.0550079
  20. Park JK, et al. Effect of Taraxaci Herba on Surgically Induced Endometriosis in Rats. The Journal of oriental obstetrics & Gynecology. 2006;19(3):69-82.
  21. Zhang Jie-bin. Jing Yue Quan Shu. Seoul:Bupin Publication. 2007:674.
  22. Kim JC, et al. Legislation clinical examination required. Seoul:Gomunsa. 1984:432-7.
  23. Lee MH, et al. Anti-inflammatory effect and contents from the aerial part and root of the various Taraxacum spp. distributed in Korea. Kor. J. Herbology. 2010;25(4):77-84.
  24. Baek HY. In Vitro Free Radical Scavenging and Hepatoprotective Activities of Taraxacum mongolicum. Kor. J. Parmocogn. 2003;12:324-6.
  25. Nationwide College of Oriental Medicine, Herbalism edited by Professor. Herbalism. Seoul:Younglim Inc. 1999:203-4.
  26. In-house test data. Daiichi Pure Chemical Methods, 6th ed. Amos. Iowastate Univ. 1967:124-5.
  27. Miller WL. Molecular biology of steroid hormone synthesis. Endocrin. Rev. 1988;9:295-318. https://doi.org/10.1210/edrv-9-3-295
  28. Hung W. Clinical Pediatric Endocrinology. Mosby Year Book, St. Louis. 1992: 228-31.
  29. Yalow R, Berson S. Introduction and general considerations. IN:Odell WD, Daughaday WH (eds): Principles of Comptitive Protein Binding Assays. Philadelphia:J. B. Lippincott Co. 1971 :1-19.
  30. Burtis CA, Ashwood ER : Tietz Textbook of Clinical Chemistry. 2nd. edition. Philadelphia:WB Saunders. 1994:1681.
  31. Kang KJ. Female Reproductive Medicine. Seoul:Daeguan publisher. 1998:63-6, 92-6.
  32. Lee JY. Hormone Replacement Therapy in Postmenopausal Women. Journal of Korean life insurance medical association. 1993;12(1):27-39.
  33. Oriental obstetrics & Gynecology. Korean obstetrics & Gynecology(sang). Seoul: Euiseongdang. 2012:265, 276, 280.
  34. Oriental obstetrics & Gynecology. Korean obstetrics & Gynecology(Ha). Seoul: Euiseongdang. 2012:201.
  35. Kim JH, et al. Acupuncture and Moxibustion Therapy for menopause syndrome : literature Review. The journal of eastwest medicine. 1998;6:16-24.
  36. College of Oriental Medicine, Herbalism Compilation Committee. Herbalism. Seoul:Younglim Inc. 2005:246.