Neutrophil-lymphocyte Ratio Findings and Larynx Carcinoma: a Preliminary Study in Turkey

  • Duzlu, Mehmet (Gazi University Faculty of Medicine Department of Otorhinolaryngology) ;
  • Karamert, Recep (Gazi University Faculty of Medicine Department of Otorhinolaryngology) ;
  • Tutar, Hakan (Gazi University Faculty of Medicine Department of Otorhinolaryngology) ;
  • Karaloglu, Furkan (Gazi University Faculty of Medicine Department of Otorhinolaryngology) ;
  • Sahin, Melih (Gazi University Faculty of Medicine Department of Otorhinolaryngology) ;
  • Cevizci, Rasit (Medipol University Faculty of Medicine Department of Otorhinolaryngology)
  • Published : 2015.02.04


Background: To identify the potential prognostic role of the neutrophil/lymphocyte (N/L) ratio in larynx carcinoma. Materials and Methods: Oncologic archive charts of patients with a larynx carcinoma diagnosis between the years 2010 and 2013 were retrospectively reviewed. The inclusion criterion was to be available with hemogram test prior to diagnostic procedure. Patients undergoing septorinoplasty comprised the control group. Results: There were 65 cases in the study and 42 cases in control group meeting inclusion criteria. In general a non-significant increase in N/L ratio was observed with increasing tumor size and stage (p>0.05) in larynx carcinoma. The N/L ratio was found to be significantly higher in larynx carcinoma compared to control group (p=0.004). Conclusions: In conclusion, the N/L ratio was shown to be significantly increased in larynx carcinomas compared to control group. Further studies are needed to assess any prognostic role.


  1. Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet, 357, 539-45.
  2. Balta S, Demirkol S, Sarlak H, Kurt O (2013). Comment on 'Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients': neutrophil to lymphocyte ratio may be predictor of mortality in patients with soft-tissue sarcoma. Br J Cancer, 108, 2625-6.
  3. Castelijns JA, van den Brekel MW, Tobi H, et al (1996). Laryngeal carcinoma after radiation therapy: Correlation of abnormal MR imaging signal patterns in laryngeal cartilage with the risk of recurrence. Radiology, 198, 151-5.
  4. Duffy BK, Gurm HS, Rajagopal V, et al (2006). Usefulness of an elevated neutrophil to lymphocyte ratio in predicting longterm mortality after percutaneous coronary intervention. Am J Cardiol, 97, 993-6.
  5. Galli J, Cammarota G, Volante M, et al (2006). Laryngeal carcinoma and laryngo-pharyngeal reflux disease. Acta Otorhinolaryngol Ital, 26, 260-3.
  6. Edge S, Byrd DR, Compton CC, et al (2010). In 7th.ed. AJCC cancer staging manual. Springer pp 57-68.
  7. Halazun KJ, Hardy MA, Rana AA, et al (2009). Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg, 250, 141-51
  8. Jin Y, Ye X, He C, Zhang B, Zhang Y (2013). Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma. Head Neck, doi: 10.1002/hed.23565 [Epub ahead of print].
  9. Kemal Y1, Yucel I, Ekiz K, et al (2014). Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev, 15, 2651-4.
  10. Kum RO, Ozcan M, Baklaci D, et al (2014). Elevated neutrophilto-lymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev. 15, 7351-5.
  11. Lee DY, Hong SW, Chang YG, Lee WY, Lee B (2013). Clinical significance of preoperative inflammatory parameters in gastric cancer patients. J Gastric Cancer, 13, 111-6.
  12. Mariani F, Sena P, Roncucci L (2014). Inflammatory pathways in the early steps of colorectal cancer development. World J Gastroenterol, 20, 9716-31.
  13. Ohno Y, Nakashima J, Ohori M, et al (2012). Follow up of neutrophil-to-lymphocyte ratio and recurrence of clear cell renal cell carcinoma. J Urol, 187, 411-7.
  14. Proctor MJ, McMillan DC, Morrison DS, et al (2012). A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer, 107, 695-9
  15. Sen N, Afsar B, Ozcan F, et al (2013). The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with STelevated myocardial infarction undergoing primary coronary intervention. Atherosclerosis, 228, 203-10.
  16. Teramukai S1, Kitano T, Kishida Y, et al (2009). Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organization LC00-03. Eur J Cancer, 45, 1590-8.
  17. Vielba R, Bilbao J, Ispizua A, et al (2003). p53 and cyclin D1 as prognostic factors in squamous cell carcinoma of the larynx. Laryngoscope, 113, 167-72.

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