- Volume 16 Issue 1
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VEGF-C and VEGF-D Expression and its Correlation with Lymph Node Metastasis in Esophageal Squamous Cell Cancer Tissue
- Yang, Zeng (Department of Thoracic Surgery, Beijing Tian Tan Hospital, Capital Medical University) ;
- Wang, Yong-Gang (Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences) ;
- Su, Kai (Department of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences)
- Published : 2015.02.04
Background: To explore vascular endothelial growth factor C (VEGF-C) and VEGF-D expression and its correlation with lymph node metastasis in esophageal squamous cell cancer (ESCC) tissue. Materials and Methods: Immunohistochemical methods were applied to detect the levels of VEGF-C and VEGF-D expression in 64 surgicall removal ESCC tissues, tissues adjacent to cancer and normal tissues, and the relationship between VEGF-C and VEGF-D expression and lymph node metastasis was analyzed. Results: Both VEGF-C and VEGF-D were expressed by varying degrees in esophageal cancer tissue, the tissue adjacent to cancer and normal tissue, and the positive expression rate went down successively. The positive expression rates of VEGF-C (59.4%) and VEGF-D (43.8%) in esophageal cancer tissue were significantly higher than in the tissue adjacent to cancer (34.4%, 15.6%) and normal tissue (20.3%, 12.5%), respectively, in which significant differences were manifested (p<0.01). Positive expression rates of VEGF-C and VEGF-D in esophageal cancers with lymph node metastasis were markedly higher than without such metastasis (p<0.01), while those in the tissue with TNM staging I~II were markedly lower than that with TNM staging III~IV (p<0.01). Conclusions: Both VEGF-C and VEGF-D are highly expressed in ESCC tissue, which may be related to the lymph node metastasis of cancer cells. Hence, VEGF-C and VEGF-D can be clinically considered as important reference indexes of lymph node metastasis in esophageal cancer.
Esophageal SCC;vascular endothelial growth factor C;VEGF D;lymph node metastasis
- Chang YW, Su CM, Su YH, et al (2014). Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects. Oncotarget, 5, 3823-35. https://doi.org/10.18632/oncotarget.1709
- Feng JF, Zhao Q, Chen QX (2013). Prognostic value of subcarinal lymph node metastasis in patients with esophageal squamous cell carcinoma. Asian Pac J Cancer Prev, 14, 3183-6. https://doi.org/10.7314/APJCP.2013.14.5.3183
- Harris NC, Davydova N, Roufail S, et al (2013). The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem, 288, 8176-86. https://doi.org/10.1074/jbc.M112.439299
- He L, He J, Zhao X (2013). Expression of VEGF-D in epithelial ovarian cancer and its relationship to lymphatic metastasis. Asia Pac J Clin Oncol, [Epub ahead of print].
- Hsu PK, Huang CS, Wang BY, et al (2013). Survival benefits of postoperative chemoradiation for lymph node-positive esophageal squamous cell carcinoma. Ann Thorac Surg, 97, 1734-41.
- Jiang JT, Zhang LF, Zhou B, et al (2012). Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis. Asian Pac J Cancer Prev, 13, 3379-83. https://doi.org/10.7314/APJCP.2012.13.7.3379
- Karaman S, Detmar M (2014). Mechanisms of lymphatic metastasis. J Clin Invest, 124, 922-8. https://doi.org/10.1172/JCI71606
- Kawai Y, Takeda A, Gershenwald JE (2003). Effects of vascular endothelial growth factor D on the signaling cascade of sentinel lymphatic endothelial cells from melanoma patients undergoing sentinel lymphadenectomy. Gan To Kagaku Ryoho, 30, 2141-4.
- Kostis G, Ioannis L, Helen K, et al (2014). The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: an immunohistochemical study. Urol Ann, 6, 224-30. https://doi.org/10.4103/0974-7796.134275
- Omoto I, Matsumoto M, Okumura H, et al (2014). Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma. Oncol Lett, 7, 1027-32.
- Sui P, Hu P, Zhang T, et al (2014). High expression of CXCR-2 correlates with lymph node metastasis and predicts unfavorable prognosis in resected esophageal carcinoma. Med Oncol, 31, 809. https://doi.org/10.1007/s12032-013-0809-z
- Sun JJ, Jing W, Ni YY, et al (2012). New model of insitu xenograft lymphangiogenesis by a human colonic adenocarcinoma cell line in nude mice. Asian Pac J Cancer Prev, 13, 2823-8. https://doi.org/10.7314/APJCP.2012.13.6.2823
- Trompezinski S, Berthier-Vergnes O, Denis A, et al (2004). Comparative expression of vascular endothelial growth factor family members, VEGF-B, -C and -D, by normal human keratinocytes and fibroblasts. Exp Dermatol, 13, 98-105. https://doi.org/10.1111/j.0906-6705.2004.00137.x
- Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review vol.47, pp.2, 2019, https://doi.org/10.1177/0300060518819606