- Volume 16 Issue 1
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Relationship between Exposure to Pesticides and Occurrence of Acute Leukemia in Iran
- Maryam, Zakerinia (Hematology Research Center, Shiraz University of Medical Sciences) ;
- Sajad, Amirghofran (Kish International Branch, Shiraz University of Medical Sciences) ;
- Maral, Namdari (Ophthalamology Department, Shiraz University of Medical Sciences) ;
- Zahra, Lesan (Adult Hematology-Oncology Ward, Shiraz University of Medical Sciences) ;
- Sima, Pooralimohamad (Adult Hematology-Oncology Ward, Shiraz University of Medical Sciences) ;
- Zeinab, Attabac (Pediatric Hematology Research Center, Oncology Ward, Shiraz University of Medical Sciences) ;
- Zahra, Mehravar (Pediatric Hematology Research Center, Oncology Ward, Shiraz University of Medical Sciences) ;
- Fariba, Ebrahimi (Pediatric Hematology Research Center, Oncology Ward, Shiraz University of Medical Sciences) ;
- Sezaneh, Haghpanah (Hematology Research Center, Shiraz University of Medical Sciences) ;
- Davood, Mehrabani (Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences)
- Published : 2015.02.04
Background: One of the causes of acute leukemia can be exposure to certain chemicals such as pesticides. This study determined the relationship between exposure to pesticides and the occurrence of acute leukemia in Fars province, south of Iran. Materials and Methods: Between April 2011 and April 2013 in a case-control study conducted in Nemazee Hospital in Shiraz, Southern Iran; 314 subjects diagnosed with acute leukemia (94 pediatric cases and 220 adults) were enrolled to determine any correlation between exposure to pesticides and the occurrence. Controls (n=314) were matched by sex and age. Results: There was a history of exposure to pesticides among 85% of pediatric cases and 69% of their controls and 83% of adult cases and 75% of their controls while 87.5% of pediatric cases and 90% of adult cases reported exposure to intermediate and high doses of pesticides and among the controls, the exposure to low doses of pesticides was 70.5% and 65%, respectively. Exposure to indoor pesticides was seen among most of cases and controls. Being a farmer was at a significantly more increased risk of developing acute leukemia in comparison to other jobs, especially for their children. Conclusions: Exposure to pesticides was shown to be one of the most important causes of acute leukemia. It seems that there is a need to educate the people on public health importance of exposure to pesticides especially during school time to reduce the risk of malignancies during childhood.
- Beard J, Sladden T, Morgan G, et al (2003). Health impacts of pesticide exposure in a cohort of outdoor workers. Environ Health Perspect, 111, 724-30.
- Beranger R, Blain J, Baudinet C, et al (2014). Testicular germ cell tumours and early exposures to pesticides: The TESTEPERA pilot study. Bull Cancer, 101, 225-35.
- Buckley JD, Robison LL, Swotinsky R, et al (1989). Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. Cancer Res, 49, 4030-7.
- Canalle R, Burim RV, Tone LG, et al (2004). Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Environ Mol Mutagen, 43, 100-9. https://doi.org/10.1002/em.20003
- Chen Z, Robison L, Giller R, et al (20060. Environmental exposure to residential pesticides, chemicals, dusts, fumes, and metals, and risk of childhood germ cell tumors. Int J Hyg Environ Health, 209, 31-40. https://doi.org/10.1016/j.ijheh.2005.08.001
- Chokkalingam AP, Metayer C, Scelo GA, et al (2012). Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control, 23, 1367-75. https://doi.org/10.1007/s10552-012-9947-4
- Costa LG (2010). Toxic effects of pesticides. In Klaassen CD, Watkins III JB. editors: Casarett & Doull's Essentials of toxicology. 2nd ed. New York; MacGraw Hill Lange; p. 309-21.
- Ferreira JD, Couto AC, Pombo-de-Oliveira MS, et al (2013). In utero pesticide exposure and leukemia in Brazilian children < 2 years of age. Environ Health Perspect, 121, 269-75.
- Gouveia-Vigeant T, Tickner J (2003). Toxic chemical and childhood cancer: a review of the evidence. A publication of the Lowell center for sustainable production. university of Massachussetts Lowell.
- Graillot V, Tomasetig F, Cravedi JP, et al (2012). Evidence of the in vitro genotoxicity of methyl-pyrazole pesticides in human cells. Mutat Res, 748, 8-16. https://doi.org/10.1016/j.mrgentox.2012.05.014
- Infante-Rivard C, Labuda D, Krajinovic M, et al (1999). Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology, 10, 481-87. https://doi.org/10.1097/00001648-199909000-00004
- Karimi M, Mehrabani D, Yarmohammadi H, et al (2008). The prevalence of signs and symptoms of childhood leukemia and lymphoma in Fars Province, Southern Iran. Cancer Detect Prev, 32, 178-83. https://doi.org/10.1016/j.cdp.2008.06.001
- Kyle AD (2001). Children, cancer, and the environment: leukemia. www.envirohealthpolicy.net.
- Lowengart RA, Peters JM, Cicioni C, et al (1987). Childhood leukemia and parents' occupational and home exposures. J Natl Cancer Inst, 79, 39-46.
- Ma X, Buffler PA, Gunier RB, et al (2002). Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect, 110, 955-60. https://doi.org/10.1289/ehp.02110955
- Matic MG, Coric VM, Savic-Radojevic AR, et al (2014). Does occupational exposure to solvents and pesticides in association with glutathione s-transferase A1, m1, p1, and t1 polymorphisms increase the risk of bladder cancer? The belgrade case-control study. PLoS One, 9, 99448. https://doi.org/10.1371/journal.pone.0099448
- Mehrabani D, Tabei SZ, Heydari ST, et al (2008). Cancer occurrence in Fars Province, Southern Iran. Iran Red Crescent Med J, 10, 314-22.
- Meinert R, Schuz J, Kaletsch U, et al (2000). Leukemia and non-Hodgkin's lymphoma in childhood and exposure to pesticides: results of a register-based case-control study in Germany. Am J Epidemiol, 151, 639-46. https://doi.org/10.1093/oxfordjournals.aje.a010256
- NCAMP home (2001). Beyound pesticides/NCAMP facts and figures children, pesticides, and schools. www.beyondpesticides.org/SEPA_fact&figures.htm.
- Nebert DW, McKinnon RA, Puga A (1996). Human drugmetabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. DNA Cell Biol, 15, 273-80. https://doi.org/10.1089/dna.1996.15.273
- NRDC (2003). Toxic chemicals and health: kids' health in depth: report, trouble on the farm, growing up with pesticides in agricultural communities: chapter 1. www.nrdc.org/health/kids/farm/chap1.asp.
- Paxion MB, Chinchilli VM, Brell SM, et al (1994). Leukemia risk associated with benzene exposure in the pliofilm cohort. I. Mortality update and expsoure distribution. Risk Anal, 14, 147-54. https://doi.org/10.1111/j.1539-6924.1994.tb00039.x
- Perera FP, Weinstein IB (2000). Molecular epidemiology: recent advances and future directions. Carcinogenesis, 21, 517-24. https://doi.org/10.1093/carcin/21.3.517
- Richardson S, Zittoun R, Bastuji-Garin S, et al (1992). Occupational risk factors for acute leukaemia: a case-control study. Int J Epidemiol, 21, 1063-73. https://doi.org/10.1093/ije/21.6.1063
- Urayama KY, Wiencke JK, Buffler PA, et al (2007). MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev, 16, 1172-7. https://doi.org/10.1158/1055-9965.EPI-07-0007
- Yildirim M, Karakilinc H, Yildiz M, et al (2013). Non-Hodgkin lymphoma and pesticide exposure in Turkey. Asian Pac J Cancer Prev, 14, 3461-3. https://doi.org/10.7314/APJCP.2013.14.6.3461
- Yildirim M, Kaya V, Yildiz M, et al (2014). Esophageal cancer, gastric cancer and the use of pesticides in the southwestern of Turkey. Asian Pac J Cancer Prev, 15, 2821-3. https://doi.org/10.7314/APJCP.2014.15.6.2821
- Zakerinia M, Namdar M, Alavi S, et al (1998). Development of hematologic malignancies and aplastic anemia following exposure to mustard gas. Iran J Med Sci, 23, 1-5.
- Zakerinia M, Namdari M, Amirghofran S (2012). The relationship between exposure to pesticides and the occurrence of lymphoid neoplasm. Iran Red Crescent Med J, 14, 337-44.
- Changing Epidemiology of Common Cancers in Southern Iran, 2007-2010: A Cross Sectional Study vol.11, pp.5, 2016, https://doi.org/10.1371/journal.pone.0155669
- Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil vol.24, pp.18, 2017, https://doi.org/10.1007/s11356-017-9150-y
- Pesticides: an update of human exposure and toxicity vol.91, pp.2, 2017, https://doi.org/10.1007/s00204-016-1849-x