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Level and Evaluation of Tumor Marker CA-125 in Ovarian Cancer Patients in Khyber Pakhtunkhwa, Pakistan

  • Ahmad, Bashir (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Nawaz, Seema (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Ali, Sajid (Department of Biotechnology, Abdul Wali Khan University of Mardan) ;
  • Bashir, Shumaila (Department of Pharmacy, University of Peshawar) ;
  • Mahmood, Nourin (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Gul, Bushra (Centre for Biotechnology and Microbiology, University of Peshawar)
  • Published : 2015.02.04

Abstract

Background: Due to the increase in morbidity and mortality rate, cancer has become an alarming threat to the human population worldwide. Since cancer is a progressive disorder, timely diagnosis is necessary to prevent/stop cancer from progressing to a severe stage. In Khyber Paktunkhwa, Pakistan, many tumors are diagnosed with endoscopy and biopsy; rare studies exist regarding the diagnosis and evaluation of ovarian cancer, based on tumor markers like CA-125. Objectives: The objectives of this study were to investigate and evaluate levels of CA-125 in hospitalized ovarian cancer patients. Materials and Methods: In this study, a total of 63 admitted patients having ovarian cancer by biopsy were included. The level of CA-125 was determined in the blood of these patients using ELISA technique. Results: Out of 63 patients, the level of CA-125 was high in 52%. The affected individuals were more in the group of 40-60 and the level of CA-125 was comparatively higher in patients having moderately differentiated histology than those having well differentiated and poorly differentiated tumor histology. Moreover, the highest level of CA-125 was present among the patients having serous subtype of carcinoma and the common stage of carcinoma was stage II followed by stage III, I and IV. Conclusions: CA-125 level was high in more than 50% of the total patients. Moreover, CA-125 elevation was more common in serous subtype and stage II cancer patients.

Keywords

Ovarian cancer;CA-125;ELISA;subtypes;Kyber, Pakistan

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