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Is Mitochondrial DNA Copy Number Associated with Clinical Characteristics and Prognosis in Gastric Cancer?

  • Lee, Hyunsu (Department of Anatomy, School of Medicine, Keimyung University) ;
  • Lee, Jae-Ho (Department of Anatomy, School of Medicine, Keimyung University) ;
  • Kim, Dong-Choon (Department of Internal Medicine, School of Medicine, Keimyung University) ;
  • Hwang, IlSeon (Department of Pathology, School of Medicine, Keimyung University) ;
  • Kang, Yu-Na (Department of Pathology, School of Medicine, Keimyung University) ;
  • Gwon, Gi-Jeong (Department of Anatomy, School of Medicine, Keimyung University) ;
  • Choi, In-Jang (Department of Anatomy, School of Medicine, Keimyung University) ;
  • Kim, Shin (Department of Immunology, School of Medicine, Keimyung University)
  • Published : 2015.02.04

Abstract

Alterations in mitochondrial DNA (mtDNA) have been studied in various cancers. However, the clinical value of mtDNA copy number (mtCN) alterations in gastric cancer (GC) is poorly understood. In the present study, we investigated whether alterations in mtCNs might be associated with clinicopathological parameters in GC cases. mtCN was measured in 109 patients with GC by quantitative real-time PCR. Then, correlations with clinicopathological characteristics were analyzed. mtCN was elevated in 64.2% of GC tissues compared with paired, adjacent, non-cancerous tissue. However, the observed alterations in mtCN were not associated with any clinicopathological characteristics, including age, gender, TN stage, Lauren classification, lymph node metastasis, and depth of invasion. Moreover, Kaplan-Meier survival curves revealed that mtCN was not significantly associated with the survival of GC patients. In this study, we demonstrated that mtCN was not a significant marker for predicting clinical characteristics or prognosis in GC.

Keywords

Gastric cancer;mitochondrial DNA;copy number;prognosis

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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