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FoxM1 as a Novel Therapeutic Target for Cancer Drug Therapy

  • Xu, Xin-Sen (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Miao, Run-Chen (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Wan, Yong (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Zhang, Ling-Qiang (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Qu, Kai (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Liu, Chang (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University)
  • Published : 2015.02.04

Abstract

Background: Current cancer therapy mainly focuses on identifying novel targets crucial for tumorigenesis. The FoxM1 is of preference as an anticancer target, due to its significance in execution of mitosis, cell cycle progression, as well as other signal pathways leading to tumorigenesis. FoxM1 is partially regulated by oncoproteins or tumor suppressors, which are often mutated, lost, or overexpressed in human cancer. Since sustaining proliferating signaling is an important hallmark of cancer, FoxM1 is overexpressed in a series of human malignancies. Alarge-scale gene expression analysis also identified FoxM1 as a differentially-expressed gene in most solid tumors. Furthermore, overexpressed FoxM1 is correlated with the prognosis of cancer patients, as verified in a series of malignancies by Cox regression analysis. Thus, extensive studies have been conducted to explore the roles of FoxM1 in tumorigenesis, making it an attractive target for anticancer therapy. Several antitumor drugs have been reported to target or inhibit FoxM1 expression in different cancers, and down-regulation of FoxM1 also abrogates drug resistance in some cancer cell lines, highlighting a promising future for FoxM1 application in the clinic.

Keywords

FoxM1;expression;prognosis;mechanism;drug resistance

Acknowledgement

Supported by : national natural science foundation of China

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