Prognostic Significance of Nestin Expression in pT1 High-Grade Bladder Urothelial Carcinoma Patients Treated with Intravesical BCG

  • Sen, Volkan (Department of Urology, School of Medicine, Dokuz Eylul University) ;
  • Bozkurt, Ozan (Department of Urology, School of Medicine, Dokuz Eylul University) ;
  • Demir, Omer (Department of Urology, School of Medicine, Dokuz Eylul University) ;
  • Tuna, Burcin (Department of Pathology, School of Medicine, Dokuz Eylul University) ;
  • Yorukoglu, Kutsal (Department of Pathology, School of Medicine, Dokuz Eylul University) ;
  • Ellidokuz, Hulya (Department of Biostatistics and Medical Informatics, School of Medicine, Dokuz Eylul University) ;
  • Mungan, Ugur (Department of Urology, School of Medicine, Dokuz Eylul University)
  • Published : 2015.01.22


Background: Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated. Materials and Methods: T1 high grade bladder cancer patients who were treated with intravesical BCG between 1990-2009 were included. Immunohistochemical staining for nestin expression was performed. Nestin(+) and nestin(-) patients were compared in terms of recurrence and progression rates. Results: Sixty-three patients were included and median follow-up time was twenty-five months. After staining; 33 patients (52.4%) were classified as nestin (+) and 30 (47.6%) as (-). Nestin (+) patients were more likely to recur compared to nestin (-) patients (60.6% vs. 30%, p<0.05). Progression rates were also higher in nestin (+) patients, although this result did not reach statistical significance (15.2 % vs. 10 %, p=0.710). Conclusions: Nestin expression, which seems effective in predicting recurrence, appears to have a potential role in the urothelial carcinoma tumorigenesis. Patients with high grade bladder cancer and positive nestin expression need close follow-up and might be informed about more tendency to recur. Further comprehensive studies including larger patient cohorts may clarify the role of nestin in bladder cancer.


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