Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status

  • Zhou, Cheng-Jiang (School of Basic Medicine, Baotou Medical College) ;
  • Zhang, Liu-Wei (Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center) ;
  • Gao, Fang (School of Basic Medicine, Baotou Medical College) ;
  • Zhang, Bin (School of Basic Medicine, Baotou Medical College) ;
  • Wang, Ying (School of Basic Medicine, Baotou Medical College) ;
  • Chen, Da-Fang (Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center) ;
  • Jia, Yan-Bin (School of Basic Medicine, Baotou Medical College)
  • Published : 2015.01.22


Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.


Supported by : National Natural Science Foundation of China


  1. Bardhan PK (1997). Epidemiological features of Helicobacter pylori infection in developing countries. Clin Infect Dis, 25, 973-8.
  2. Cao XY, Jia ZF, Cao DH, et al (2013). DNMT3a rs1550117 polymorphism association with increased risk of Helicobacter pylori infection. Asian Pac J Cancer Prev, 14, 5713-8.
  3. Farinati F, Valiante F, Germana B, et al (1993). Prevalence of Helicobacter pylori infection in patients with precancerous changes and gastric cancer. Eur J Cancer Prev, 2, 321-6.
  4. Graham DY, Malaty HM, Evans DG, et al (1991). Epidemiology of Helicobacter pylori in an asymptomatic population in the United States: effect of age, race, and socioeconomic status. Gastroenterology, 100, 1495-501.
  5. Ho SB, Takamura K, Anway R, et al (2004). The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig Dis Sci, 49, 1598-606.
  6. Jia Y, Persson C, Hou L, et al (2010). A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. Cancer Causes Control, 21, 313-21.
  7. Kocer B, Ulas M, Ustundag Y, et al (2004). A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression. J Clin Gastroenterol, 38, 496-502.
  8. Lillehoj EP, Guang W, Ding H, Czinn SJ, Blanchard TG (2012). Helicobacter pylori and gastric inflammation: role of MUC1 mucin. J Pediatr Biochem, 2, 125-32.
  9. Linden S, Semino-Mora C, Liu H, Rick J, Dubois A (2010). Role of mucin Lewis status in resistance to Helicobacter pylori infection in pediatric patients. Helicobacter, 15, 251-8.
  10. Linden SK, Wickstrom C, Lindell G, Gilshenan K, Carlstedt I (2008). Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches. Helicobacter, 13, 81-93.
  11. Malaty HM, Engstrand L, Pedersen NL, Graham DY (1994). Helicobacter pylori infection: genetic and environmental influences: a study of twins. Ann intern Med, 120, 982-6.
  12. Malaty HM, Graham DY, Isaksson I, Engstrand L, Pedersen NL (1998). Co-twin study of the effect of environment and dietary elements on acquisition of Helicobacter pylori infection. Am J Epidemiol, 148, 793-7.
  13. Mayerle J, den Hoed CM, Schurmann C, et al (2013). Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA, 309, 1912-20.
  14. Osman HA, Hasan H, Suppian R, et al (2014). Evaluation of the Atlas Helicobacter pylori stool antigen test for diagnosis of infection in adult patients. Asian Pac J Cancer Prev, 15, 5245-7.
  15. Peek RM Jr, Blaser MJ (2002). Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer, 2, 28-37.
  16. Van de Bovenkamp JH, Mahdavi J, Korteland-Van Male AM, et al (2003). The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. Helicobacter, 8, 521-32.
  17. Wang, RQ, Fang DC (2006). Effects of Helicobacter pylori infection on mucin expression in gastric carcinoma and pericancerous tissues. J Gastroenterol Hepatol, 21, 425-31.
  18. Zhao Y, Wang J, Tanaka T, et al (2012). Association between HLA-DQ genotypes and haplotypes vs Helicobacter pylori infection in an Indonesian population. Asian Pac J Cancer Prev, 13, 1247-51.
  19. Zheng Z, Jia Y, Persson C, et al (2009). Genetic variation in $\alpha$4GnT in relation to Helicobacter pylori serology and gastric cancer risk. Helicobacter, 14, 120-5.
  20. Zhou CJ, Zhang LW, Gao F, et al (2014). Association analysis of common genetic variations in MUC5AC gene with the risk of non-cardia gastric cancer in a Chinese population. Asian Pac J Cancer Prev, 15, 4207-10

Cited by

  1. MUC1, MUC5AC, and MUC6 polymorphisms, Helicobacter pylori infection, and gastric cancer pp.0959-8278, 2017,